A new nipple position measure to enhance atlas-based segmentation in breast cancer radiotherapy planning.

IF 1.8 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Anri Minamitake, Ryuji Murakami, Kenichi Kai, Yasuhiro Doi, Hironori Hayashi
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引用次数: 0

Abstract

Objectives: This technical report describes a method for template selection in atlas-based segmentation (ABS) for breast cancer that uses breast volume and nipple position.

Methods: Fifty patients who underwent postoperative radiotherapy (RT) after breast-conserving surgery were included. An experienced radiation oncologist manually segmented the bilateral breasts and recorded parameters including breast volume and nipple position. Nipple position was defined as the vertical distance from the midsternal skin to the nipple base on axial computed tomography. A radiation technologist subjectively selected eight patients as templates and generated an ABS using each template for the remaining 49 cases (392 template-case pairs, 784 breast pairs). The Dice similarity coefficient (DSC) was used to assess the agreement between ABS and manual segmentation. Both breasts were evaluated simultaneously without consideration of the differences between the ipsilateral and contralateral operated sides. The Mann-Whitney U-test and Kruskal-Wallis test were used to compare DSC values among groups based on breast parameters.

Results: Breast volume (P < 0.001) and nipple position (P < 0.001) were significant parameters for template selection in the 784 breast pairs. Selecting templates with breast volumes that were half to double those of the test case while maintaining the dorsal nipple position relative to the test case resulted in a median DSC of 0.88.

Conclusions: Breast volume and nipple position are valuable parameters that can improve template selection in ABS for breast cancer.

Advances in knowledge: We developed a new nipple position measure to enhance ABS in breast cancer RT planning.

一种新的乳头位置测量方法在乳腺癌放疗计划中增强基于图谱的分割。
目的:本技术报告描述了一种使用乳房体积和乳头位置的基于图谱的乳腺癌分割(ABS)模板选择方法。方法:对50例保乳术后放疗患者进行回顾性分析。一位经验丰富的放射肿瘤学家手动分割双侧乳房并记录包括乳房体积和乳头位置在内的参数。乳头位置定义为在轴向计算机断层扫描上胸骨中部皮肤到乳头基部的垂直距离。放射技师主观选择8例患者作为模板,对其余49例(392对模板-病例,784对乳房)使用每个模板生成ABS。使用Dice相似系数(DSC)来评估ABS与手动分割之间的一致性。同时评估两个乳房,不考虑同侧和对侧手术侧的差异。采用Mann-Whitney u检验和Kruskal-Wallis检验比较各组乳腺参数的DSC值。结果:乳房体积(P)结论:乳房体积和乳头位置是改善乳腺癌ABS模板选择的重要参数。知识进展:我们开发了一种新的乳头位置测量方法,以增强乳腺癌放疗计划中的ABS。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
British Journal of Radiology
British Journal of Radiology 医学-核医学
CiteScore
5.30
自引率
3.80%
发文量
330
审稿时长
2-4 weeks
期刊介绍: BJR is the international research journal of the British Institute of Radiology and is the oldest scientific journal in the field of radiology and related sciences. Dating back to 1896, BJR’s history is radiology’s history, and the journal has featured some landmark papers such as the first description of Computed Tomography "Computerized transverse axial tomography" by Godfrey Hounsfield in 1973. A valuable historical resource, the complete BJR archive has been digitized from 1896. Quick Facts: - 2015 Impact Factor – 1.840 - Receipt to first decision – average of 6 weeks - Acceptance to online publication – average of 3 weeks - ISSN: 0007-1285 - eISSN: 1748-880X Open Access option
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