Emerging Contaminants: An Important But Ignored Risk Factor for Psoriasis.

IF 8.4 2区 医学 Q1 ALLERGY
Leyi Huang, Yinli Zhou, Hui Xiao, Yajia Li, Zhiru Zhou, Ziyi Xiao, Yixuan Tong, Kun Hu, Yehong Kuang, Minxue Shen, Yi Xiao, Xiang Chen
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Abstract

Industrialization and modernization have changed the environment. A group of emerging contaminants (ECs) has been defined recently. Psoriasis, whose incidence has increased in recent years, is a relapsing immune-mediated disease carrying a heavy disease burden. The erythematous scaly plaque is a typical symptom and occurs on several parts of the body. In addition, psoriasis has many comorbidities, such as psoriatic arthritis, diabetes, and depression, damaging the quality of life of patients. IL-17, IL-12, IL-23, and TNF-alpha are important related cytokines. ECs can influence psoriasis through the immune system and inflammatory responses. Specific mechanisms include increasing pro-inflammatory cytokines such as TNF-α and IL-17, and activating immune cells such as macrophages. And for psoriasis patients, it is suggested to reduce the exposure of most ECs. However, the complex mechanisms involved have not been discussed together and concluded. In this review, we summarize the relationship between ECs and psoriasis, focusing on the immune system, especially the immune cells and cytokines. These results can help guide clinical treatment and long-term management of psoriasis.

新出现的污染物:银屑病的一个重要但被忽视的危险因素。
工业化和现代化改变了环境。一组新兴污染物(ECs)最近被定义。银屑病是一种复发性免疫介导疾病,近年来发病率有所上升,疾病负担沉重。红斑鳞状斑块是一种典型的症状,发生在身体的几个部位。此外,银屑病有许多合并症,如银屑病关节炎、糖尿病、抑郁症等,损害患者的生活质量。IL-17、IL-12、IL-23和tnf - α是重要的相关细胞因子。ECs可以通过免疫系统和炎症反应影响牛皮癣。具体机制包括增加促炎细胞因子如TNF-α和IL-17,激活免疫细胞如巨噬细胞。对于银屑病患者,建议减少大部分ECs的暴露。然而,所涉及的复杂机制尚未共同讨论并得出结论。本文就ECs与银屑病的关系作一综述,重点从免疫系统,特别是免疫细胞和细胞因子等方面进行综述。这些结果有助于指导银屑病的临床治疗和长期管理。
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来源期刊
CiteScore
22.30
自引率
1.10%
发文量
58
审稿时长
6-12 weeks
期刊介绍: Clinical Reviews in Allergy & Immunology is a scholarly journal that focuses on the advancement of clinical management in allergic and immunologic diseases. The journal publishes both scholarly reviews and experimental papers that address the current state of managing these diseases, placing new data into perspective. Each issue of the journal is dedicated to a specific theme of critical importance to allergists and immunologists, aiming to provide a comprehensive understanding of the subject matter for a wide readership. The journal is particularly helpful in explaining how novel data impacts clinical management, along with advancements such as standardized protocols for allergy skin testing and challenge procedures, as well as improved understanding of cell biology. Ultimately, the journal aims to contribute to the improvement of care and management for patients with immune-mediated diseases.
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