The Link Between Respiratory Syncytial Virus-Induced Lower Respiratory Tract Infection and Type 2 Inflammation in Asthma.

IF 1 4区医学 Q3 PEDIATRICS

Clinical Pediatrics Pub Date : 2025-03-24 DOI:10.1177/00099228251321597

Bei Ye, Shu Teng, Lu Zhan

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引用次数: 0

Abstract

Objective: To investigate the relationship between the type 2 inflammatory response associated with asthma and lower respiratory tract infection (LRTI) caused by respiratory syncytial virus (RSV).

Methods: Sixty-seven children with RSV infection hospitalized in our hospital from October 2023 to December 2023 and 27 healthy children undergoing medical examination were included. The study population was divided into the RSV LRTI group (n = 67) and the control group (n = 27). Interleukin-13 (IL-13), serum total immunoglobulin E (IgE), mucin 5AC (MUC5AC), and blood eosinophil count (EOS) were tested and compared between the two groups. The presence or absence of specificity between the two groups was analyzed using the rank sum test and subject operating characteristic curves (Receiver Operating Characteristic curves, ROC curves).

Results: The levels of IL-13, IgE, MUC5AC, and EOS were higher in children with RSV LRTI compared to healthy children. These differences were statistically significant (P < .05). The ROC curve analysis results showed that IL-13, IgE, MUC5AC, and EOS predicted type 2 inflammation with areas under the curve of 0.687, 0.762, 0.764, and 0.646, respectively.

Conclusion: A type 2 inflammatory response associated with asthma may be observed after RSV-induced LRTIs.

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呼吸道合胞病毒诱导下呼吸道感染与哮喘2型炎症的关系

目的：探讨呼吸道合胞病毒（RSV）所致下呼吸道感染（LRTI）与哮喘相关2型炎症反应的关系。方法：选取2023年10月至2023年12月在我院住院的67例呼吸道合胞病毒感染患儿和27例健康体检患儿。研究人群分为RSV - LRTI组（n = 67）和对照组（n = 27）。检测两组患者白细胞介素-13 （IL-13）、血清总免疫球蛋白E （IgE）、粘蛋白5AC （MUC5AC）、血嗜酸性粒细胞计数（EOS）。采用秩和检验和受试者工作特征曲线（Receiver operating characteristic curves， ROC曲线）分析两组间是否存在特异性。结果：RSV下呼吸道感染患儿血清IL-13、IgE、MUC5AC、EOS水平均高于健康儿童。差异有统计学意义（P < 0.05）。ROC曲线分析结果显示，IL-13、IgE、MUC5AC、EOS预测2型炎症的曲线下面积分别为0.687、0.762、0.764、0.646。结论：rsv诱导下呼吸道感染后可能出现与哮喘相关的2型炎症反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Pediatrics 医学-小儿科

CiteScore

2.10

自引率

6.20%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Clinical Pediatrics (CLP) a peer-reviewed monthly journal, is a must read for the busy pediatrician. CLP contains state-of-the-art, accurate, concise and down-to earth information on practical, everyday child care topics whether they are clinical, scientific, behavioral, educational, or ethical.