Establishing the baseline: understanding follicle activation morphometrics in multiple mammalian species.

IF 3.1 2区 生物学 Q2 REPRODUCTIVE BIOLOGY
Hana Kubo, Christopher J McCauley, Mary B Zelinski, Monica M Laronda
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引用次数: 0

Abstract

Folliculogenesis encompasses many stages as the somatic granulosa and theca cells support oocytes through growth and maturation. A novel follicle stage, between primordial and transitional stages, was identified in mice and defined as "zip". Like all other follicle stages, the "zip" stage is characterized by its granulosa cell morphology. The "wedge" GC morphology in zip follicles is predicted to be the first granulosa cell division, marking the transition from squamous to cuboidal morphology. Here, zip and transitional stages were identified in histological sections of porcine, bovine, rhesus monkey, and human ovaries. Several growth dynamics characterized at these follicle stages were conserved between species. Oocyte diameter and area increased between the primordial and transitional stages in the porcine ovary and between the primordial and primary stages in the rhesus monkey ovary but appeared unchanged in bovine and human ovaries. In all species except for pigs, granulosa cell number and height increased at stages earlier than observed changes in the oocyte. Furthermore, there were differences in the percentage of zip and transitional follicle stages present in the cortical region across species. This implies that there may be species-dependent activation and growth mechanisms that require further study. The parameters defined here for identifying and characterizing the zip and transitional follicle stages across species can act as a tool for measuring factors that perturb or induce primordial follicle activation or effect follicle morphometric parameters in support of future innovations for fertility preservation and restoration.

建立基线:了解多种哺乳动物物种的卵泡激活形态计量学。
卵泡发生包括许多阶段,因为体细胞颗粒和卵膜细胞通过生长和成熟支持卵母细胞。在小鼠中发现了一个介于原始和过渡阶段之间的新卵泡阶段,并将其定义为“zip”。像所有其他卵泡期一样,“zip”期的特征是其颗粒状细胞形态。zip卵泡的“楔形”GC形态被预测为颗粒细胞的第一次分裂,标志着从鳞状到立方体形态的转变。本文在猪、牛、恒河猴和人类卵巢的组织学切片中发现了zip和过渡阶段。在这些卵泡阶段的几个生长动力学特征在物种之间是保守的。猪卵巢的卵母细胞直径和卵母细胞面积在初始阶段和过渡阶段有所增加,恒河猴卵巢的卵母细胞直径和卵母细胞面积在初始阶段和过渡阶段有所增加,而牛和人卵巢的卵母细胞直径和卵母细胞面积基本不变。除猪外,所有物种的颗粒细胞数量和高度的增加都早于卵母细胞的变化。此外,在皮层区存在的zip和过渡卵泡阶段的百分比在不同物种之间存在差异。这意味着可能存在物种依赖的激活和生长机制,需要进一步研究。这里定义的参数用于识别和表征跨物种的压缩和过渡卵泡阶段,可以作为测量干扰或诱导原始卵泡激活或影响卵泡形态测量参数的因素的工具,以支持未来的生育保存和恢复创新。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biology of Reproduction
Biology of Reproduction 生物-生殖生物学
CiteScore
6.30
自引率
5.60%
发文量
214
审稿时长
1 months
期刊介绍: Biology of Reproduction (BOR) is the official journal of the Society for the Study of Reproduction and publishes original research on a broad range of topics in the field of reproductive biology, as well as reviews on topics of current importance or controversy. BOR is consistently one of the most highly cited journals publishing original research in the field of reproductive biology.
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