Therapeutic importance of hydrogen sulfide in cognitive impairment diseases

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-03-20 DOI:10.1016/j.brainres.2025.149547

Hai-Jun Wei , Hui-Ying Tan , Jian-Ping Cao , Juan He , Qing-Li Zhang , Li Jiang , Gui-Juan Zhou , Fan Xiao

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引用次数: 0

Abstract

The brain naturally synthesizes hydrogen sulfide (H₂S) via enzymes such as cystathionine-β-synthase (CBS), 3-mercaptopyruvate sulfurtransferase (3-MST), cysteine aminotransferase (CAT), and cystathionine-γ-lyase (CSE). From a physiological point of view, H₂S serves as a neuromodulator with antioxidant and neuroprotective properties. Recent research suggests that H₂S is crucial in regulating learning and memory, as its downregulation is commonly observed in cognitive impairment diseases. Preclinical studies suggest that external supplementation, through donors like sodium hydrosulfide (NaHS), can improve cognitive impairment in various cognitive disorder models. Moreover, numerous molecular mechanisms have been proposed to explain the effects of these H₂S donors. This review aims to detail the roles of H₂S in various models of cognitive impairment and in human subjects, highlighting its potential mechanisms and providing experimental support for its use as a novel therapeutic approach in treating cognitive disorders. Overall, H₂S plays a significant role in the treatment of cognitive impairment diseases, but further large-scale studies are still required to support the results of current research.

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硫化氢在认知功能障碍疾病中的治疗意义。

大脑通过半胱甘氨酸-β-合成酶（CBS）、3-巯基丙酮酸硫转移酶（3-MST）、半胱氨酸氨基转移酶（CAT）和半胱甘氨酸-γ-裂解酶（CSE）等酶自然合成硫化氢（H2S）。从生理学的角度来看，H2S是一种具有抗氧化和神经保护特性的神经调节剂。最近的研究表明，H2S在调节学习和记忆中起着至关重要的作用，因为它的下调通常在认知障碍疾病中观察到。临床前研究表明，通过氢硫化钠（NaHS）等供体进行外部补充，可以改善各种认知障碍模型的认知障碍。此外，已经提出了许多分子机制来解释这些H2S供体的作用。本文旨在详细介绍H2S在各种认知障碍模型和人类受试者中的作用，强调其潜在机制，并为其作为治疗认知障碍的新方法提供实验支持。总体而言，H2S在认知功能障碍疾病的治疗中发挥了重要作用，但仍需要进一步的大规模研究来支持当前的研究结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.