Glyphosate-based herbicide as a potential risk factor for breast cancer

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology Pub Date : 2025-03-21 DOI:10.1016/j.fct.2025.115404

Lyvia Neves Rebello Alves , Luiza Poppe Merigueti , Matheus Correia Casotti , Bruno Cancian de Araújo , Raquel Silva dos Reis Trabach , Maria do Carmo Pimentel Batitucci , Débora Dummer Meira , Flávia de Paula , Eldamária de Vargas Wolfgramm dos Santos , Iúri Drumond Louro

{"title":"Glyphosate-based herbicide as a potential risk factor for breast cancer","authors":"Lyvia Neves Rebello Alves , Luiza Poppe Merigueti , Matheus Correia Casotti , Bruno Cancian de Araújo , Raquel Silva dos Reis Trabach , Maria do Carmo Pimentel Batitucci , Débora Dummer Meira , Flávia de Paula , Eldamária de Vargas Wolfgramm dos Santos , Iúri Drumond Louro","doi":"10.1016/j.fct.2025.115404","DOIUrl":null,"url":null,"abstract":"<div><div>Breast cancer is the most common neoplasm in women worldwide, with both genetic and environmental factors playing a role in its development. Glyphosate, the active ingredient in widely used agricultural herbicides, is recognized as a potential carcinogen and endocrine disruptor, making it a candidate for inducing epigenetic modifications linked to breast cancer. This study investigates the effects of the glyphosate-based herbicide Roundup® on non-tumorigenic (MCF10A) and tumorigenic (MCF7 and MDA-MB-231) breast cell lines, focusing on the expression of key breast cancer-related genes. Additionally, the study examines the association with epigenetic modifications and the use of epidrugs to reverse potential alterations, aiming to understand the risks and mechanisms of herbicide action. Results indicate that Roundup® affects cells through a non-estrogenic mechanism, impacting both hormone-dependent and -independent cells with varying toxic and proliferative effects depending on dose and exposure time. Moreover, it altered the expression of breast cancer-related genes such as <em>BRCA1</em> and <em>BRCA2</em> at low doses. The use of epigenetic modulators was able to reverse some Roundup®-induced changes, suggesting the herbicide's role in epigenetic modifications. Overall, these findings highlight the importance of understanding glyphosate-based herbicide mechanisms in humans, which could enable personalized prevention strategies to mitigate breast cancer risks.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115404"},"PeriodicalIF":3.9000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food and Chemical Toxicology","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0278691525001723","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Breast cancer is the most common neoplasm in women worldwide, with both genetic and environmental factors playing a role in its development. Glyphosate, the active ingredient in widely used agricultural herbicides, is recognized as a potential carcinogen and endocrine disruptor, making it a candidate for inducing epigenetic modifications linked to breast cancer. This study investigates the effects of the glyphosate-based herbicide Roundup® on non-tumorigenic (MCF10A) and tumorigenic (MCF7 and MDA-MB-231) breast cell lines, focusing on the expression of key breast cancer-related genes. Additionally, the study examines the association with epigenetic modifications and the use of epidrugs to reverse potential alterations, aiming to understand the risks and mechanisms of herbicide action. Results indicate that Roundup® affects cells through a non-estrogenic mechanism, impacting both hormone-dependent and -independent cells with varying toxic and proliferative effects depending on dose and exposure time. Moreover, it altered the expression of breast cancer-related genes such as BRCA1 and BRCA2 at low doses. The use of epigenetic modulators was able to reverse some Roundup®-induced changes, suggesting the herbicide's role in epigenetic modifications. Overall, these findings highlight the importance of understanding glyphosate-based herbicide mechanisms in humans, which could enable personalized prevention strategies to mitigate breast cancer risks.

Abstract Image

查看原文本刊更多论文

草甘膦除草剂是乳腺癌的潜在危险因素。

乳腺癌是全世界女性中最常见的肿瘤，遗传和环境因素在其发展中起着重要作用。草甘膦是广泛使用的农业除草剂中的有效成分，被认为是一种潜在的致癌物质和内分泌干扰物，因此它是诱发与乳腺癌相关的表观遗传修饰的候选者。本研究探讨草甘膦除草剂农达对非致瘤性（MCF10A）和致瘤性（MCF7和MDA-MB-231）乳腺细胞系的影响，重点研究乳腺癌相关关键基因的表达。此外，该研究还研究了表观遗传修饰和使用外用药物逆转潜在改变的关系，旨在了解除草剂作用的风险和机制。结果表明，农达®通过非雌激素机制影响细胞，影响激素依赖性和非依赖性细胞，并根据剂量和暴露时间产生不同的毒性和增殖作用。此外，它在低剂量下改变了乳腺癌相关基因如BRCA1和BRCA2的表达。表观遗传调节剂的使用能够逆转农达引起的一些变化，这表明除草剂在表观遗传修饰中的作用。总的来说，这些发现强调了了解草甘膦除草剂在人类中的作用机制的重要性，这可以实现个性化的预防策略，以降低乳腺癌的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Food and Chemical Toxicology 工程技术-毒理学

CiteScore

10.90

自引率

4.70%

发文量

651

审稿时长

31 days

期刊介绍： Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derived products, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs. The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter. Studies should address at least one of the following: -Adverse physiological/biochemical, or pathological changes induced by specific defined substances -New techniques for assessing potential toxicity, including molecular biology -Mechanisms underlying toxic phenomena -Toxicological examinations of specific chemicals or consumer products, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability. Authors must clearly and briefly identify what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is in the abstract. Furthermore, sufficient doses should be included in order to provide information on NOAEL/LOAEL values.