Oxidative Stress, DNA Damage, Ethoxyresorufin-O-deethylase Induction and Neurotoxicity Caused by Environmental Pollutants in Cyprinus carpio (Linnaeus, 1758) from Atatürk Dam Lake (Türkiye).
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引用次数: 0
Abstract
Increasing population, industrial developments and agricultural activities around Atatürk Dam Lake, the largest dam of Türkiye, are also increasing level of pollutants in this reservoir. Catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA), ethoxyresorufin-O-deethylase (EROD), 8-Hydroxy-2'-deoxyguanosine (8-OHdG), and acetylcholinesterase (AChE) in tissues of Cyprinus carpio caught from Samsat (relatively clean), Sitilce (affected by domestic/industrial wastes) and Bozova (affected by agricultural activities) regions of dam lake were analyzed in this work. Significant declines in SOD, AChE and GSH (P < 0.05) and significant elevations in CAT, EROD, 8-OHdG and MDA (P < 0.05) were observed in fish from Sitilce and Bozova regions compared to Samsat region. In Sitilce and Bozova, while these elevations were 54% and 121% for EROD, 40% and 92% for 8-OHdG, these declines were 33% and 58% for SOD, 29% and 55% for AChE, respectively. Our research shows environmental pollutants cause oxidative damage and neurotoxicity in fish from Atatürk Dam Lake.
环境污染物对 rkiye湖鲤(Cyprinus carpio, Linnaeus, 1758)氧化应激、DNA损伤、乙氧基间苯二酚- o -去乙基酶诱导及神经毒性的影响
atatatrk大坝湖是trkiye最大的大坝,随着人口的增长,工业发展和农业活动,该水库的污染物水平也在增加。本文分析了在Samsat(相对清洁)、Sitilce(受生活/工业废弃物影响)和Bozova(受农业活动影响)流域捕获的鲤鱼组织中过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、丙二醛(MDA)、乙氧基间苯二酚- o -去乙基化酶(EROD)、8-羟基-2′-脱氧鸟苷(8-OHdG)和乙酰胆碱酯酶(AChE)的含量。SOD、AChE、GSH明显下降(P
期刊介绍:
The Bulletin of Environmental Contamination and Toxicology(BECT) is a peer-reviewed journal that offers rapid review and publication. Accepted submissions will be presented as clear, concise reports of current research for a readership concerned with environmental contamination and toxicology. Scientific quality and clarity are paramount.