Design and synthesis of a clickable cell-permeable pseudopeptide Pin1 inhibitor with antiproliferative effects on human multiple myeloma cell line†

Abstract

The synthesis of a library of minimal-backbone, cell-permeable, clickable pseudopeptide Pin1 ligands with potential applications in drug development and biochemical studies is reported. The ligands’ affinity constants were evaluated using NMR. The lead compound , demonstrated effective cell permeability, inhibitory activity, and an antiproliferative effect on a multiple myeloma cell line.