Alcohol consumption and risk of early onset colorectal cancer: A systematic review and meta-analysis

IF 2.9 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Colorectal Disease Pub Date : 2025-03-24 DOI:10.1111/codi.70046

Siyu Huang, Lulin Yu, Fengchun Xiong, Bo Zhang, Shanming Ruan

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引用次数: 0

Abstract

Aim

The existing evidence has shown a positive association between alcohol consumption and an increased risk of colorectal cancer (CRC). However, the evidence is primarily based on studies of CRC in all ages, and the role of alcohol in early onset colorectal cancer (EOCRC) remains to be determined. The aim of this study was to investigate an association between the increasing incidence of EOCRC and alcohol consumption.

Method

We systematically searched PubMed, EMBASE, Cochrane and Web of Science up to June 2024 for studies that evaluated the association of alcohol intake with EOCRC risk and report specific results (e.g. relative risk, OR or hazard ratio and corresponding 95% CI). Based on the varying designs of the included studies, the corresponding effect values were extracted and categorized into high alcohol consumption and low alcohol consumption groups; a random-effects model was adopted to estimate the pooled effect sizes for analysis. Furthermore, subgroup analyses and publication bias assessments were conducted.

Results

Three cohort studies and eight case–control studies were eligible and included. The results were pooled in meta-analyses, which yielded a heightened risk of EOCRC for increased alcohol intake (OR = 1.56, 95% CI 1.28–1.89, I² = 89.3%). In the subgroup analysis, no significant differences were found in the association between alcohol consumption and the risk of developing EOCRC across gender, location or tumour site. The results of sensitivity analysis and publication bias indicated that the conclusion was robust.

Conclusions

This meta-analysis provides possible evidence for an association between alcohol consumption and risk of EOCRC. More research is needed in the future to confirm these findings.

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饮酒与早发性结直肠癌的风险：一项系统综述和荟萃分析

现有证据表明，饮酒与结直肠癌（CRC）风险增加之间存在正相关。然而，这些证据主要是基于对所有年龄段结直肠癌的研究，酒精在早发性结直肠癌（EOCRC）中的作用仍有待确定。本研究的目的是调查EOCRC发病率增加与饮酒之间的关系。方法系统检索PubMed、EMBASE、Cochrane和Web of Science，检索截至2024年6月评估酒精摄入与EOCRC风险相关性的研究，并报告具体结果（如相对风险、OR或风险比和相应的95% CI）。根据纳入研究的不同设计，提取相应的效应值并将其分为高饮酒量组和低饮酒量组；采用随机效应模型估计合并效应量以供分析。此外，进行亚组分析和发表偏倚评估。结果纳入了3项队列研究和8项病例对照研究。荟萃分析结果显示，酒精摄入量增加会增加EOCRC的风险（OR = 1.56, 95% CI 1.28-1.89, I2 = 89.3%）。在亚组分析中，没有发现饮酒与不同性别、部位或肿瘤部位发生EOCRC风险之间存在显著差异。敏感性分析和发表偏倚结果表明，结论是稳健的。结论：本荟萃分析为饮酒与EOCRC风险之间的关联提供了可能的证据。未来需要更多的研究来证实这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colorectal Disease 医学-胃肠肝病学

CiteScore

6.10

自引率

11.80%

发文量

406

审稿时长

1.5 months

期刊介绍： Diseases of the colon and rectum are common and offer a number of exciting challenges. Clinical, diagnostic and basic science research is expanding rapidly. There is increasing demand from purchasers of health care and patients for clinicians to keep abreast of the latest research and developments, and to translate these into routine practice. Technological advances in diagnosis, surgical technique, new pharmaceuticals, molecular genetics and other basic sciences have transformed many aspects of how these diseases are managed. Such progress will accelerate. Colorectal Disease offers a real benefit to subscribers and authors. It is first and foremost a vehicle for publishing original research relating to the demanding, rapidly expanding field of colorectal diseases. Essential for surgeons, pathologists, oncologists, gastroenterologists and health professionals caring for patients with a disease of the lower GI tract, Colorectal Disease furthers education and inter-professional development by including regular review articles and discussions of current controversies. Note that the journal does not usually accept paediatric surgical papers.