Immunology in Osseointegration After Implantation

IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL
Yuyang Liu, Min Gao, Yikun Yan, Xue Wang, Zhihong Dong, Lijia Cheng, Yaji Xu
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Abstract

Bone tissue is renowned for its regenerative capabilities, yet handling extensive defects and complex fractures presents considerable medical challenges. Osteoimmunology, studying the complex mechanism of the mutual influence within the range of immunity and skeletal systems, has highlighted the indispensable function of immune reactions in the process of bone integration. This procedure, primarily immune-driven, fosters new bone formation around implants instead of relying solely on osteogenic mechanisms. Traditionally, implant research has emphasized bone bonding and osteoinduction, often overlooking the significant influence of immune interactions. Implants pose risks including donor site morbidity, decreased bioactivity, and pathogen transmission risks. To mitigate these, implant surfaces are modified through altering local factors such as electrical fields and applying physical treatments to change roughness, hydrophilicity, and nanotopography. These modifications aim to regulate immune reactions at the surface of the bone implant, improving osseointegration and the repair of bone. This review examines the types of immune cells in osseointegration, especially the pivotal function that macrophages serve in the regeneration of bone tissue, and investigates key implant features—morphology, wettability, cytokine interaction, and metal ion and bioactive molecule adsorption—that impact immune responses. These insights underscore the immune system's importance in bone repair and advance osteoimmunology as essential for developing strategies to control bone immune responses, enhancing implant integration and bone regeneration.

植入后骨整合的免疫学研究
骨组织以其再生能力而闻名,但处理大面积缺损和复杂骨折提出了相当大的医学挑战。骨免疫学研究了免疫与骨骼系统相互影响的复杂机制,强调了免疫反应在骨整合过程中不可或缺的作用。这个过程主要是免疫驱动的,在植入物周围促进新骨形成,而不是仅仅依靠成骨机制。传统上,种植体研究强调骨结合和骨诱导,往往忽略了免疫相互作用的重要影响。植入物带来的风险包括供体部位发病率、生物活性降低和病原体传播风险。为了减轻这些问题,通过改变局部因素(如电场)和应用物理处理来改变植入物表面的粗糙度、亲水性和纳米形貌。这些修饰旨在调节骨种植体表面的免疫反应,改善骨整合和骨修复。本文综述了骨整合中的免疫细胞类型,特别是巨噬细胞在骨组织再生中的关键功能,并研究了影响免疫反应的种植体的关键特征-形态学,润湿性,细胞因子相互作用,金属离子和生物活性分子吸附。这些发现强调了免疫系统在骨修复中的重要性,并推动了骨免疫学在制定控制骨免疫反应、增强种植体整合和骨再生策略方面的重要作用。
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来源期刊
CiteScore
7.50
自引率
2.90%
发文量
199
审稿时长
12 months
期刊介绍: Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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