{"title":"Immunology in Osseointegration After Implantation","authors":"Yuyang Liu, Min Gao, Yikun Yan, Xue Wang, Zhihong Dong, Lijia Cheng, Yaji Xu","doi":"10.1002/jbm.b.35566","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Bone tissue is renowned for its regenerative capabilities, yet handling extensive defects and complex fractures presents considerable medical challenges. Osteoimmunology, studying the complex mechanism of the mutual influence within the range of immunity and skeletal systems, has highlighted the indispensable function of immune reactions in the process of bone integration. This procedure, primarily immune-driven, fosters new bone formation around implants instead of relying solely on osteogenic mechanisms. Traditionally, implant research has emphasized bone bonding and osteoinduction, often overlooking the significant influence of immune interactions. Implants pose risks including donor site morbidity, decreased bioactivity, and pathogen transmission risks. To mitigate these, implant surfaces are modified through altering local factors such as electrical fields and applying physical treatments to change roughness, hydrophilicity, and nanotopography. These modifications aim to regulate immune reactions at the surface of the bone implant, improving osseointegration and the repair of bone. This review examines the types of immune cells in osseointegration, especially the pivotal function that macrophages serve in the regeneration of bone tissue, and investigates key implant features—morphology, wettability, cytokine interaction, and metal ion and bioactive molecule adsorption—that impact immune responses. These insights underscore the immune system's importance in bone repair and advance osteoimmunology as essential for developing strategies to control bone immune responses, enhancing implant integration and bone regeneration.</p>\n </div>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 4","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of biomedical materials research. Part B, Applied biomaterials","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.35566","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Bone tissue is renowned for its regenerative capabilities, yet handling extensive defects and complex fractures presents considerable medical challenges. Osteoimmunology, studying the complex mechanism of the mutual influence within the range of immunity and skeletal systems, has highlighted the indispensable function of immune reactions in the process of bone integration. This procedure, primarily immune-driven, fosters new bone formation around implants instead of relying solely on osteogenic mechanisms. Traditionally, implant research has emphasized bone bonding and osteoinduction, often overlooking the significant influence of immune interactions. Implants pose risks including donor site morbidity, decreased bioactivity, and pathogen transmission risks. To mitigate these, implant surfaces are modified through altering local factors such as electrical fields and applying physical treatments to change roughness, hydrophilicity, and nanotopography. These modifications aim to regulate immune reactions at the surface of the bone implant, improving osseointegration and the repair of bone. This review examines the types of immune cells in osseointegration, especially the pivotal function that macrophages serve in the regeneration of bone tissue, and investigates key implant features—morphology, wettability, cytokine interaction, and metal ion and bioactive molecule adsorption—that impact immune responses. These insights underscore the immune system's importance in bone repair and advance osteoimmunology as essential for developing strategies to control bone immune responses, enhancing implant integration and bone regeneration.
期刊介绍:
Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats:
• original research reports
• short research and development reports
• scientific reviews
• current concepts articles
• special reports
• editorials
Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.