Newly Developed Calcium-Enriched Hemostatic Sponge Enhanced Wound Healing and Regeneration

IF 3.2 4区医学 Q2 ENGINEERING, BIOMEDICAL

Journal of biomedical materials research. Part B, Applied biomaterials Pub Date : 2025-03-24 DOI:10.1002/jbm.b.35568

Ika Dewi Ana, Gumilang Almas Pratama Satria, Rahmi Anggraeni, Any Lestari, Roesita Dwi Aprilia, Rudi Wigianto, Sri Yuliana, Yasuhiko Tabata

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Abstract

This study focuses on the development, characterization, and validation of a carbonate apatite (CHA)-enriched hemostatic sponge and the evaluation of its ability to enhance wound healing and regeneration through the controlled release of calcium ions (Ca²⁺). CHA, a bioactive material resembling the natural apatite in human bone, was synthesized within gelatin matrices to form a composite sponge. The synthesis incorporated β-type carbonate ion substitutions in the CHA structure, enabling dynamic dissolution and the gradual release of Ca²⁺ ions at the site of injury. This targeted release was shown to accelerate wound healing and tissue regeneration without causing irritation. The presence of calcium ions in the CHA composite was identified as a critical factor in supporting hemostatic processes, emphasizing their importance in wound care. The CHA-enriched hemostatic sponge demonstrated superior healing outcomes, positioning it as a promising next-generation biomedical device for hemostatic purposes and wound regeneration applications. Moreover, the CHA structure offers potential for surface modifications to introduce additional functionalities, such as inherent antimicrobial properties, further enhancing its biological performance and expanding its applications in advanced wound care.

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新开发的富钙止血海绵促进伤口愈合和再生

本研究的重点是开发、表征和验证富含碳酸盐磷灰石（CHA）的止血海绵，并评估其通过控制释放钙离子（Ca2+）促进伤口愈合和再生的能力。CHA是一种生物活性材料，与人体骨骼中的天然磷灰石相似，在明胶基质中合成，形成一种复合海绵。这种合成方法在 CHA 结构中加入了 β 型碳酸根离子替代物，使其能够动态溶解，并在损伤部位逐渐释放 Ca2+ 离子。事实证明，这种定向释放可加速伤口愈合和组织再生，且不会造成刺激。钙离子在 CHA 复合材料中的存在被认为是支持止血过程的关键因素，强调了其在伤口护理中的重要性。富含 CHA 的止血海绵显示出卓越的愈合效果，使其有望成为用于止血和伤口再生应用的下一代生物医学设备。此外，CHA 结构为表面改性提供了潜力，可引入更多的功能，如固有的抗菌特性，从而进一步提高其生物性能，扩大其在高级伤口护理中的应用。

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来源期刊

Journal of biomedical materials research. Part B, Applied biomaterials 工程技术-材料科学：生物材料

CiteScore

7.50

自引率

2.90%

发文量

199

审稿时长

12 months

期刊介绍： Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.