A Retrospective Evaluation of Serum Symmetric Dimethylarginine Concentration in Dogs With Protein-Losing Enteropathy

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine Pub Date : 2025-03-24 DOI:10.1111/jvim.70068

Yeon Joon Park, Alexander J. German, David Brewer, Erin O'Connell

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Abstract

Background

Serum symmetric dimethylarginine (SDMA) is abnormally increased in people with inflammatory bowel disease (IBD). Changes in dogs with gastrointestinal disease, such as protein-losing enteropathy (PLE), have not been assessed.

Objectives

Evaluate SDMA concentration in non-azotemic dogs with PLE.

Animals

A total of 127 client-owned dogs, 17 with PLE, 34 controls matched for age, breed, sex, and neuter status, and 76 additional controls for multiple linear regression modeling.

Methods

Retrospective case–control study. The clinical records of a United Kingdom referral hospital were reviewed. Dogs with azotemia or prior glucocorticoid or immunosuppressive treatment were excluded. Dogs diagnosed with PLE that had serum symmetric dimethylarginine (SDMA) concentrations measured were compared with the matched controls. Signalment, clinical presentation, clinicopathological abnormalities, treatment, and SDMA concentration pre- (PLE-T0) and post- (PLE-T1) treatment were recorded.

Results

At baseline, SDMA concentration was higher in PLE (T0, 15.2 ± 2.02 μg/dL) than in control (11.0 ± 3.13 μg/dL) dogs (p < 0.001; Hedge's G, 1.48), but decreased with treatment (PLE-T1: 10.3 ± 2.78 μg/dL; T0 vs. T1: p = 0.01, Hedge's G, 1.31). Serum creatinine concentration was similar in PLE (T0, 0.81 ± 0.24 μg/dL) and control (0.85 ± 0.26 μg/dL) dogs at baseline (p = 0.57; Hedge's G, 0.18). Serum albumin concentration was lower in PLE (1.60 ± 0.51 g/dL) than in control (2.96 ± 0.49 g/dL) dogs (p < 0.001; Hedge's G, 2.68) before treatment, but increased with treatment (PLE-T1: 2.29 ± 0.65 g/dL; T0 vs. T1: p = 0.003; Hedge's G, 1.14), although it remained lower than the concentration in controls (p = 0.002; Hedge's G, 1.23). No other clinicopathological differences were evident.

Conclusions and Clinical Importance

Serum SDMA concentration is increased in dogs with PLE; the clinical relevance of this finding requires further investigation.

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背景炎症性肠病（IBD）患者的血清对称二甲基精氨酸（SDMA）会异常升高。目前尚未对患有胃肠道疾病（如蛋白丢失性肠病（PLE））的狗的血清二甲基精氨酸（SDMA）变化进行评估。目标评估患有 PLE 的非氮质血症犬体内的 SDMA 浓度。动物共有 127 只客户饲养的狗，其中 17 只患有 PLE，34 只对照组在年龄、品种、性别和绝育状况方面与之匹配，另外 76 只对照组用于多元线性回归建模。方法回顾性病例对照研究。研究人员查阅了英国一家转诊医院的临床记录。排除了氮质血症或曾接受糖皮质激素或免疫抑制治疗的犬只。将确诊为 PLE 并测量了血清对称二甲基精氨酸（SDMA）浓度的犬只与匹配的对照组进行比较。记录信号、临床表现、临床病理异常、治疗以及治疗前（PLE-T0）和治疗后（PLE-T1）的SDMA浓度。结果在基线时，PLE 的 SDMA 浓度（T0，15.2 ± 2.02 μg/dL）高于对照组（11.0 ± 3.13 μg/dL）（p < 0.001; Hedge's G, 1.48），但随着治疗的进行而降低（PLE-T1：10.3 ± 2.78 μg/dL；T0 vs. T1：p = 0.01, Hedge's G, 1.31）。PLE 狗（T0，0.81 ± 0.24 μg/dL）和对照组狗（0.85 ± 0.26 μg/dL）的血清肌酐浓度在基线时相似（p = 0.57；Hedge's G，0.18）。治疗前，PLE 狗的血清白蛋白浓度（1.60 ± 0.51 g/dL）低于对照组（2.96 ± 0.49 g/dL）（p = 0.001；Hedge's G，2.68），但随着治疗的进行，白蛋白浓度有所增加（PLE-T1：2.29 ± 0.65 g/dL; T0 vs. T1: p = 0.003; Hedge's G, 1.14），但仍低于对照组的浓度（p = 0.002; Hedge's G, 1.23）。其他临床病理学差异并不明显。结论和临床意义患有 PLE 的犬血清 SDMA 浓度升高；这一发现的临床意义需要进一步研究。

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来源期刊

Journal of Veterinary Internal Medicine 农林科学-兽医学

CiteScore

4.50

自引率

11.50%

发文量

243

审稿时长

22 weeks

期刊介绍： The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.