The Complex Inflammatory and Nutritional Indices to Predict Prognostic Risk for Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

Abstract

Purpose

To investigate the role of the systemic inflammatory response index (SIRI) and high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels in predicting the risk of major adverse cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).

Patients and Methods

Overall, 1377 patients with ACS who underwent PCI between January 2016 and December 2018 were consecutively enrolled. The patients were divided into MACEs (n = 60) and non-MACEs (n = 1317) groups. The study endpoints were MACEs, including cardiac-related mortality and rehospitalization for severe heart failure (HF), myocardial infarction (MI), and in-stent restenosis.

Results

Both groups showed significant differences in the patients with age > 65 years, history of HF, acute MI, cardiogenic shock, left ventricular ejection fraction < 40%, SIRI ≥ 2.848, SIRI/HDL-C ≥ 1.977, and SIRI × LDL-C ≥ 4.609. The Kaplan–Meier curve showed that the low SIRI group had higher cumulative survival than the high SIRI group. Additionally, the univariate and multivariate Cox proportional hazards model demonstrated that SIRI ≥ 2.848, SIRI/HDL-C ≥ 1.977, and SIRI × LDL-C ≥ 4.609 were independent risk factors for patients with ACS undergoing PCI. Restricted cubic spline models were generated to visualize the relationship between SIRI, SIRI/HDL-C, and SIRI × LDL-C and the prognostic risk.

Conclusion

SIRI ≥ 2.848, SIRI/HDL-C ≥ 1.977, and SIRI × LDL-C ≥ 4.609 were all independent prognostic risk factors in patients with ACS undergoing PCI, which may be useful markers for assessment for long prognosis.