SARS-CoV-2 Infection Aggravates Physical and Mental Health in Cancer Patients Compared to Co-Living Individuals

IF 2.9 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2025-03-25 DOI:10.1002/cam4.70795

Jiayao Liu, Na Li, Bin Wang, Wujie Zhao, Jie Zhi, Xiaojing Jia, Yitao Jia, Yanqing Tie

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Abstract

Introduction

Cancer patients are particularly vulnerable to the psychological sequels of COVID-19 due to their immunocompromised state and the disruptions to their regular oncological care. There is limited research comparing the effects of SARS-CoV-2 on cancer patients and their co-living individuals. This study aims to explore the similarities and differences in physical and psychological outcomes between these two groups, with a 1-year follow-up to assess long-term effects.

Methods

This retrospective observational study was conducted between January and February 2023. A total of 107 participants were included: 72 cancer patients and 35 co-living individuals, all diagnosed with COVID-19. Clinical and laboratory data were collected. Depression, anxiety, and fatigue were assessed at two timepoints: shortly after COVID-19 diagnosis and 1 year later.

Results

Cancer patients exhibited higher rates of gastrointestinal symptoms, such as diarrhea (20.83% vs. 5.71%, p = 0.045), which were associated with increased anxiety and depression (p < 0.05). Advanced-stage cancer (p < 0.01) and lack of vaccination (p < 0.01) correlated with worse psychological outcomes. Female cancer patients reported higher depression scores (p < 0.05). Laboratory findings indicated higher neutrophil percentages (p < 0.001), fibrinogen (p < 0.001), and D-dimer levels (p = 0.015) in cancer patients, signaling a higher risk of inflammation and thrombosis. Both groups showed improvements in depression and fatigue over the 1-year follow-up, but cancer patients continued to report greater psychological distress (p < 0.001) and fatigue (p = 0.024).

Conclusion

Cancer patients infected with COVID-19 experienced more severe physical and psychological symptoms compared to their co-living individuals, with persistent differences 1 year after infection.

Trial Registration

ChiCTR2300067577

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.