Association of Helicobacter pylori Infection and Risk of Dyslipidemia: A Systematic Review and Meta-Analysis

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

JGH Open Pub Date : 2025-03-24 DOI:10.1002/jgh3.70128

Ankita Gaonkar, Quazi Syed Zahiruddin, Muhammed Shabil, Soumya V. Menon, Mandeep Kaur, Mukesh Kumari, Puneet Sudan, K. Satyam Naidu, Shailendra Thapliyal, Jyoti Uikey, Rachna Kathuria, Sanjay Singh Chauhan, Lokesh Verma, Amritpal Sidhu, Ganesh Bushi, Rohimah Binti Md Yusoff, Rachana Mehta, Prakasini Satapathy, Sanjit Sah

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Abstract

Background

Although Helicobacter pylori (H. pylori) infections are widespread throughout the world, it is yet unknown whether they are linked to systemic illnesses like dyslipidemia. The purpose of this systematic review and meta-analysis was to examine the connection between lipid metabolism and H. pylori infection, with a particular emphasis on how it affects dyslipidemia.

Methods

We conducted a thorough search up until October 10, 2024, across databases such as PubMed, Web of Science, and Embase. Studies that reported lipid profiles in both H. pylori-infected and non-infected patients were considered eligible. The primary outcomes were triglyceride, LDL-C, HDL-C, and total cholesterol levels, which were examined using a random-effects model in R software version 4.4.

Results

There were 17 studies with more than 150,000 participants from 681 screened publications. Higher levels of LDL (MD: 5.32 mg/dL; 95% CI: 1.315 to 9.319) and total cholesterol (MD: 6.28 mg/dL; 95% CI: 0.718 to 11.842), as well as lower levels of HDL (MD: −2.06 mg/dL; 95% CI: −3.212 to −0.915), were the results of the meta-analysis. Among those infected, triglyceride levels were likewise higher (MD: 7.93 mg/dL; 95% CI: 0.413 to 15.436), but the odds ratio (OR) did not show a significant increase in risk (OR: 1.002; 95% CI: 0.995 to 1.010).

Conclusion

H. pylori infection is associated with significant dyslipidemia, suggesting a potential link between chronic bacterial infection and lipid metabolism. The findings emphasize the need for further research to explore the mechanisms and potential therapeutic interventions.

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幽门螺杆菌感染与血脂异常风险的关系：一项系统综述和荟萃分析

虽然幽门螺杆菌感染在世界范围内广泛存在，但尚不清楚它们是否与血脂异常等全身性疾病有关。本系统综述和荟萃分析的目的是研究脂质代谢与幽门螺杆菌感染之间的联系，特别强调它如何影响血脂异常。方法通过PubMed、Web of Science、Embase等数据库进行全面检索，检索时间截止到2024年10月10日。报告幽门螺杆菌感染和非感染患者的脂质谱的研究被认为是合格的。主要结果是甘油三酯、LDL-C、HDL-C和总胆固醇水平，使用R软件4.4版中的随机效应模型进行检测。结果共有17项研究，来自681份筛选出版物的15万多名参与者。较高水平的低密度脂蛋白(MD: 5.32 mg/dL；95% CI: 1.315 ~ 9.319)和总胆固醇(MD: 6.28 mg/dL；95% CI: 0.718至11.842)，以及较低水平的HDL (MD:−2.06 mg/dL；95% CI:−3.212 ~−0.915)，为meta分析的结果。在感染者中，甘油三酯水平同样较高(MD: 7.93 mg/dL；95% CI: 0.413 ~ 15.436)，但比值比（OR）未显示风险显著增加(OR: 1.002；95% CI: 0.995 ~ 1.010)。结论幽门螺杆菌感染与明显的血脂异常有关，提示慢性细菌感染与脂质代谢之间存在潜在联系。研究结果强调需要进一步研究以探索其机制和潜在的治疗干预措施。

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