Investigating the Efficacy of Silver Anethum graveolens Nano-Extract in Colon Cancer Radiotherapy

IF 1.9 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

ChemistrySelect Pub Date : 2025-03-19 DOI:10.1002/slct.202405345

Farshad Seyed Nejad, Mostafa Alizade-Harakiyan, Mehdi Haghi, Rokhsareh Ebrahimi, Mohammad Mahdi Zangeneh, Alireza Farajollahi, Roghayeh Fathi, Reza Mohammadi, Samira Samadi Miandoab, Mohammad Heydarnezhad Asl, Baharak Divband, Amin Ahmadi

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引用次数: 0

Abstract

Magnetic silver nanoparticles are intelligent magnetic particles that have high intelligence and a large absorption surface area. Their small size and wide absorption surface make them effective drug carriers to the cancer site. In this research, the properties of the green formulation of silver nanoparticles by Anethum graveolens on colon carcinoma cells were checked. The Ag-bionanoparticles synthesized using green formulation underwent characterization through FT-IR, XRD, EDS-mapping, and SEM techniques. The aim of this work is to study the decrease in cell viability and BCL2 expression and the increase in BAX expression with silver nanoparticles (AgNPs) synthesized using Anethum graveolens extract, especially when combined with radiation therapy. By performing MTT assay, cell survival and by qPCR assay, expression of pro-apoptotic BAX and anti-apoptotic BCL2 were evaluated. With more clinical trials, these green synthesized nanoparticles can be used to treat colon cancer.

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来源期刊

ChemistrySelect Chemistry-General Chemistry

CiteScore

3.30

自引率

4.80%

发文量

1809

审稿时长

1.6 months

期刊介绍： ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.