Translational research on pandemic virus infection using nonhuman primate models

IF 2.8 3区医学 Q3 VIROLOGY

Virology Pub Date : 2025-03-22 DOI:10.1016/j.virol.2025.110511

Hirohito Ishigaki , Yasushi Itoh

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引用次数: 0

Abstract

After the COVID-19 pandemic, nonhuman primate (NHP) models, which are necessary for the rapid development of vaccines and new medical therapies, have become important in studies on infectious diseases because of their genetic, metabolic, and immunological similarities to humans. Our group has long been using NHP models in studies on infectious diseases including H1N1 influenza pandemic and COVID-19. Despite limitations such as the limited number of animals and the husbandry requirements, NHP models have contributed to the prediction of the pathogenicity of emerging viruses and the evaluation of the efficacy of vaccines and therapeutics due to the similarity of NHP models to humans before starting clinical trials to select good candidates of vaccines and drugs. In this review, the findings obtained in NHP infectious disease models of influenza and COVID-19 are summarized to clarify the benefits of NHP models for studies on infectious diseases. We believe that this review will support future research in exploring new perspectives for the development of vaccines and therapies targeting influenza, COVID-19, and infectious diseases in future pandemics.

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利用非人类灵长类动物模型对大流行性病毒感染的转化研究

COVID-19 大流行之后，非人灵长类动物（NHP）模型因其与人类在遗传、代谢和免疫学方面的相似性，成为快速开发疫苗和新医疗方法的必要条件，并在传染病研究中发挥了重要作用。长期以来，我们的研究小组一直使用 NHP 模型进行包括 H1N1 流感大流行和 COVID-19 在内的传染病研究。尽管存在动物数量有限和饲养要求高等局限性，但由于 NHP 模型与人类相似，因此在开始临床试验之前，NHP 模型为预测新出现病毒的致病性以及评估疫苗和治疗药物的疗效做出了贡献，从而筛选出好的候选疫苗和药物。在本综述中，总结了在流感和 COVID-19 的 NHP 传染病模型中取得的研究成果，以阐明 NHP 模型在传染病研究中的益处。我们相信，这篇综述将为未来的研究提供支持，为开发针对流感、COVID-19 和未来大流行传染病的疫苗和疗法探索新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Virology 医学-病毒学

CiteScore

6.00

自引率

0.00%

发文量

157

审稿时长

50 days

期刊介绍： Launched in 1955, Virology is a broad and inclusive journal that welcomes submissions on all aspects of virology including plant, animal, microbial and human viruses. The journal publishes basic research as well as pre-clinical and clinical studies of vaccines, anti-viral drugs and their development, anti-viral therapies, and computational studies of virus infections. Any submission that is of broad interest to the community of virologists/vaccinologists and reporting scientifically accurate and valuable research will be considered for publication, including negative findings and multidisciplinary work.Virology is open to reviews, research manuscripts, short communication, registered reports as well as follow-up manuscripts.