Investigating the memory-preserving potential of L-carnitine and memantine in an aluminum-induced memory deficit model

IF 1.7 4区心理学 Q3 PSYCHOLOGY, BIOLOGICAL

Learning and Motivation Pub Date : 2025-03-22 DOI:10.1016/j.lmot.2025.102125

Imran Imran , Muhammad Numair Kashif , Sana Ameer , Nosheen Malik , Abida Parveen , Waseem Ashraf , Asad Abrar , Faleh Alqathani , Tanveer Ahmad

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引用次数: 0

Abstract

Aluminum exposure in daily life results in significant neurotoxicity and leads to progressive neurodegenerative disorders and there is a dire need for counteracting agents. The current study investigated the possible ameliorative effect of L-carnitine with memantine against AlCl₃-induced memory impairment in male mice. AlCl₃ (100 mg/kg) was administered orally to all groups except a healthy one. Treatment groups were administered with L-carnitine 100 mg/kg, memantine 10 mg/kg and a combination group with L-carnitine 100 mg/kg and memantine 10 mg/kg for 42 days. The behavioral changes were examined using Y-maze, NOR, PAT and MWM tests. The biochemical and histopathological parameters were quantified in isolated brains. The outcomes revealed amelioration of learning and memory through better alterations in the Y-maze test, better recognition of a novel object in NOR, increased step-through latency in PAT and reduced latencies to reach the platform in the MWM test. The biochemical analysis revealed suppression of lipid oxidation through regulation of antioxidant content and inhibition of AChE. The histopathological findings demonstrated significant protection of neuronal cells in CA1 and DG regions against AlCl₃-induced damage. Outcomes of this study suggested that memantine combined with L-carnitine is an ably option to halt the progression of neuronal cell degeneration in various neurologic disorders.

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研究左旋肉碱和美金刚在铝诱导的记忆缺陷模型中的记忆保留潜力

日常生活中接触铝会导致严重的神经毒性，并导致进行性神经退行性疾病，因此迫切需要抗铝剂。本研究探讨了左旋肉碱联合美金刚对alcl3诱导的雄性小鼠记忆损伤的可能改善作用。除健康组外，其余各组均口服AlCl3（100 mg/kg）。治疗组分别给予左旋肉碱100 mg/kg、美金刚10 mg/kg，联合给予左旋肉碱100 mg/kg、美金刚10 mg/kg，连用42 d。采用y型迷宫、NOR、PAT和MWM测试检测行为变化。在离体脑组织中定量测定生化和组织病理学参数。结果显示，通过y迷宫测试中更好的改变，NOR测试中对新物体的更好识别，PAT测试中步进延迟增加，MWM测试中到达平台的延迟减少，学习和记忆得到改善。生化分析表明，通过调节抗氧化剂含量和抑制AChE抑制脂质氧化。组织病理学结果表明，CA1和DG区域的神经元细胞对alcl3诱导的损伤具有显著的保护作用。这项研究的结果表明，美金刚联合左旋肉碱是一种有效的选择，以阻止各种神经系统疾病的神经元细胞退化的进展。

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来源期刊

Learning and Motivation Multiple-

CiteScore

2.90

自引率

0.00%

发文量

期刊介绍： Learning and Motivation features original experimental research devoted to the analysis of basic phenomena and mechanisms of learning, memory, and motivation. These studies, involving either animal or human subjects, examine behavioral, biological, and evolutionary influences on the learning and motivation processes, and often report on an integrated series of experiments that advance knowledge in this field. Theoretical papers and shorter reports are also considered.