Two-dimensional nanozyme nanoarchitectonics customized electrochemical bio diagnostics and lab-on-chip devices for biomarker detection

IF 15.9 1区化学 Q1 CHEMISTRY, PHYSICAL

Advances in Colloid and Interface Science Pub Date : 2025-03-19 DOI:10.1016/j.cis.2025.103474

Thenmozhi Rajarathinam , Sivaguru Jayaraman , Chang-Seok Kim , Jang-Hee Yoon , Seung-Cheol Chang

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引用次数: 0

Abstract

Recent developments in nanomaterials and nanotechnology have advanced biosensing research. Two-dimensional (2D) nanomaterials or nanozymes, such as metal oxides, graphene and its derivatives, transition metal dichalcogenides, metal-organic frameworks, carbon-organic frameworks and MXenes, have garnered substantial attention in recent years owing to their unique properties, including high surface area, excellent electrical conductivity, and mechanical flexibility. Moreover, 2D nanozymes exhibit intrinsic enzyme-mimicking properties, including those of peroxidase, oxidase, catalase, and superoxide dismutase, making them well-suited for detecting biomarkers of interest and developing bio diagnostics at the point-of-care. Since 2D nanosystems offer ultra-high sensitivity, label-free detection, and real-time analysis, point-of-care testing and multiplexed biomarker detection, the demand is growing. Additionally, their biocompatibility and scalable fabrication make them cost-effective for widespread adoption. This review discusses the advantages of 2D nanozymes and their recent advancements in biosensing applications. This review summarizes the latest developments in 2D nanozymes, focusing on their synthesis, biocatalytic capabilities, and advancements in developing bio diagnostics and lab-on-chip devices for detecting cancer and non-cancer biomarkers. In addition, existing challenges and prospects in 2D nanozyme-based biosensors are identified, highlighting their biosensing potential and advocating for their expanded application in bio diagnostics and lab-on-chip devices.

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来源期刊

Advances in Colloid and Interface Science 化学-物理化学

CiteScore

28.50

自引率

2.60%

发文量

175

审稿时长

31 days

期刊介绍： "Advances in Colloid and Interface Science" is an international journal that focuses on experimental and theoretical developments in interfacial and colloidal phenomena. The journal covers a wide range of disciplines including biology, chemistry, physics, and technology. The journal accepts review articles on any topic within the scope of colloid and interface science. These articles should provide an in-depth analysis of the subject matter, offering a critical review of the current state of the field. The author's informed opinion on the topic should also be included. The manuscript should compare and contrast ideas found in the reviewed literature and address the limitations of these ideas. Typically, the articles published in this journal are written by recognized experts in the field.