Plant sphingolipids: Subcellular distributions and functions

Abstract

Sphingolipids are common membrane components that maintain membrane structural integrity and function as signaling molecules. Different sphingolipids have specific functions and are unevenly distributed across the membranes of various organelles and subcellular compartments. In this review, we survey the sphingolipidomes of different subcellular structures in Arabidopsis (Arabidopsis thaliana) cells and provide a detailed account of the functions of specific sphingolipids at each location. For example, glycosphingolipids, including glucosylceramide and glycosyl inositol phosphoceramide, mainly function in membranes, whereas simple sphingolipids, including free long-chain bases and ceramide, may have important signaling roles in the plasma membrane, mitochondria, and nucleus during plant stress responses and cell death. This review thus offers a broad perspective of the multifaceted roles of plant sphingolipids in different locations in the plant cell.