The Klingler's brain dissection technique: Review of the original procedure and technical considerations

Q3 Medicine

Translational Research in Anatomy Pub Date : 2025-03-20 DOI:10.1016/j.tria.2025.100393

Andrzej Żytkowski , Jakub Dębski , Stanisław Orkisz

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引用次数: 0

Abstract

Background

The Klingler's brain dissection technique, originally introduced by Ludwig Klingler in 1935, can be considered an useful research toll for investigating the structural organization of white matter tracts in the human brain. The method involves freezing formalin-fixed brain tissue, which facilitates the separation of fiber tracts, making it a crucial tool for both neuroanatomical education and research on brain connectivity.

Aim

Given the practical relevance of this technique in both research and neurosurgical training, this review aims to recall the original Klingler's method, analyze key modifications introduced in recent years, and evaluate its significance in contemporary anatomical and neuroimaging research.

Conclusions

The Klingler's fiber dissection technique remains a cornerstone of neuroanatomical research, particularly in combination with modern imaging techniques such as tractography. Its ability to reveal the three-dimensional architecture of white matter fibers has solidified its role in both anatomical education and neurosurgical planning.

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来源期刊

Translational Research in Anatomy Medicine-Anatomy

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

25 days

期刊介绍： Translational Research in Anatomy is an international peer-reviewed and open access journal that publishes high-quality original papers. Focusing on translational research, the journal aims to disseminate the knowledge that is gained in the basic science of anatomy and to apply it to the diagnosis and treatment of human pathology in order to improve individual patient well-being. Topics published in Translational Research in Anatomy include anatomy in all of its aspects, especially those that have application to other scientific disciplines including the health sciences: • gross anatomy • neuroanatomy • histology • immunohistochemistry • comparative anatomy • embryology • molecular biology • microscopic anatomy • forensics • imaging/radiology • medical education Priority will be given to studies that clearly articulate their relevance to the broader aspects of anatomy and how they can impact patient care.Strengthening the ties between morphological research and medicine will foster collaboration between anatomists and physicians. Therefore, Translational Research in Anatomy will serve as a platform for communication and understanding between the disciplines of anatomy and medicine and will aid in the dissemination of anatomical research. The journal accepts the following article types: 1. Review articles 2. Original research papers 3. New state-of-the-art methods of research in the field of anatomy including imaging, dissection methods, medical devices and quantitation 4. Education papers (teaching technologies/methods in medical education in anatomy) 5. Commentaries 6. Letters to the Editor 7. Selected conference papers 8. Case Reports