Sodium channel blockers for the treatment of focal epilepsy: A Chinese expert consensus

IF 2.7 3区医学 Q2 CLINICAL NEUROLOGY

Seizure-European Journal of Epilepsy Pub Date : 2025-03-12 DOI:10.1016/j.seizure.2025.02.016

Raowei Yan , Hesheng Zhang , Zhen Hong , Weiping Liao , Xuefeng Wang , Yuping Wang , Bo Xiao , Yanchun Deng , Meiping Ding , Xiong Han , Shuli Liang , Weihong Lin , Xiaorong Liu , Xuewu Liu , Xin Wang , Tiancheng Wang , Xiangqing Wang , Xiaoshan Wang , Peimin Yu , Kai Zhang , Dong Zhou

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引用次数: 0

Abstract

Purpose

To provide consensus-based recommendations for the use of sodium channel blockers (SCBs) in the management of focal epilepsy.

Methods

A three-round modified Delphi procedure was conducted among a Delphi panel of 24 Chinese experts to build a consensus. A steering committee developed 9 statements related to SCBs for the treatment of focal epilepsy, and these statements were evaluated and voted upon by the expert panel.

Results

The expert panel achieved consensus on nine statements regarding the treatment recommendations for oxcarbazepine, lamotrigine, lacosamide, eslicarbazepine, topiramate, zonisamide and cenobamate in focal epilepsy patients and treatment adjustments for SCBs.

Conclusion

This is a Chinese expert consensus on the use of SCBs in focal epilepsy developed using the modified Delphi method. These recommendations can help clinicians in their practice and guide future research.

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钠通道阻滞剂治疗局灶性癫痫：中国专家共识

目的为局灶性癫痫患者应用钠通道阻滞剂（SCBs）提供共识性建议。方法对24名中国专家进行三轮修正德尔菲程序，建立共识。指导委员会制定了9项与SCBs治疗局灶性癫痫有关的声明，并由专家小组对这些声明进行了评估和投票。结果专家组就奥卡西平、拉莫三嗪、拉科沙胺、埃斯卡巴西平、托吡酯、唑尼沙胺和辛奥巴酸治疗局灶性癫痫患者的建议以及scb的治疗调整达成了9项共识。结论采用改进的德尔菲法对scb在局灶性癫痫中的应用形成了国内专家共识。这些建议可以帮助临床医生在他们的实践和指导未来的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seizure-European Journal of Epilepsy 医学-临床神经学

CiteScore

5.60

自引率

6.70%

发文量

231

审稿时长

34 days

期刊介绍： Seizure - European Journal of Epilepsy is an international journal owned by Epilepsy Action (the largest member led epilepsy organisation in the UK). It provides a forum for papers on all topics related to epilepsy and seizure disorders.