Advancing Alzheimer’s disease therapy through engineered exosomal Macromolecules

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-03-20 DOI:10.1016/j.brainres.2025.149590

Smita Jain, Ankita Murmu, Aparna Chauhan

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引用次数: 0

Abstract

Exosomes are a subject of continuous investigation due to their function as extracellular vesicles (EVs) that significantly contribute to the pathophysiology of certain neurodegenerative disorders (NDD), including Alzheimer’s disease (AD). Exosomes have shown the potential to carry both therapeutic and pathogenic materials; hence, researchers have used exosomes for medication delivery applications. Exosomes have reduced immunogenicity when used as natural drug delivery vehicles. This guarantees the efficient delivery of the medication without causing significant side reactions. Exosomes have lately enabled the potential for drug delivery in AD, along with promising future therapeutic uses for the detection of neurodegenerative disorders. Furthermore, exosomes have been examined for their prospective use in illness diagnosis and prediction before the manifestation of symptoms. This review will document prior studies and will concentrate on the rationale behind the substantial potential of exosomes in the treatment of AD and their prospective use as a diagnostic and predictive tool for this condition.

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通过工程外泌体大分子推进阿尔茨海默病治疗

外泌体作为细胞外囊泡（EVs）的功能，在包括阿尔茨海默病（AD）在内的某些神经退行性疾病（NDD）的病理生理中起着重要作用，因此一直是研究的主题。外泌体已显示出携带治疗性和致病性物质的潜力；因此，研究人员已经将外泌体用于药物输送应用。外泌体用作天然药物递送载体时，免疫原性降低。这保证了药物的有效输送，而不会引起明显的副作用。外泌体最近在阿尔茨海默病中具有潜在的药物输送潜力，同时在神经退行性疾病的检测方面具有前景广阔的未来治疗用途。此外，外泌体在症状出现前的疾病诊断和预测方面的应用前景也得到了研究。这篇综述将记录先前的研究，并将集中于外泌体在治疗阿尔茨海默病中的巨大潜力背后的基本原理，以及它们作为这种疾病的诊断和预测工具的潜在用途。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.