Altered white matter topological network and cognitive function in patients with major depressive disorder

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging Pub Date : 2025-03-19 DOI:10.1016/j.pscychresns.2025.111984

Peiwei Xu , Jing Huang , Xiu Yan , Xueli Sun , Yingying Pan

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引用次数: 0

Abstract

Objective

This study aims to explore the association between cognitive impairment and white matter topological networks in patients with major depressive disorder (MDD).

Methods

We enrolled 51 patients diagnosed with MDD and 57 healthy controls for this study. Cognitive function was evaluated using the MATRICS Consensus Cognitive Battery. Diffusion tensor imaging magnetic resonance scans were performed to construct white matter brain networks based on deterministic fiber tracts and we quantified the topological properties of these networks. Then, we investigated the potential association between changes in these network properties and cognitive dysfunction.

Results

MDD patients performed significantly worse in all cognitive domains, including speed of processing, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition. In MDD, there was a positive correlation between local efficiency and processing speed, as well as reasoning and problem solving. Additionally, the local efficiency of the right precuneus was positively correlated with verbal learning.

Conclusion

Cognitive symptoms in MDD patients may relate to dysfunction in white matter topological network.

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重度抑郁症患者白质拓扑网络与认知功能的改变

目的探讨重度抑郁障碍（MDD）患者认知功能障碍与脑白质拓扑网络的关系。方法入选51例重度抑郁症患者和57例健康对照。认知功能使用matrix共识认知电池进行评估。通过扩散张量成像磁共振扫描，构建了基于确定性纤维束的脑白质网络，并量化了这些网络的拓扑特性。然后，我们研究了这些网络特性的变化与认知功能障碍之间的潜在关联。结果smdd患者在加工速度、注意/警觉性、工作记忆、语言学习、视觉学习、推理和解决问题、社会认知等各认知领域均表现较差。在MDD中，局部效率与处理速度、推理能力和问题解决能力呈正相关。此外，右侧楔前叶的局部效率与语言学习呈正相关。结论重度抑郁症患者的认知症状可能与脑白质拓扑网络功能紊乱有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry Research: Neuroimaging 医学-精神病学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

22.5 weeks

期刊介绍： The Neuroimaging section of Psychiatry Research publishes manuscripts on positron emission tomography, magnetic resonance imaging, computerized electroencephalographic topography, regional cerebral blood flow, computed tomography, magnetoencephalography, autoradiography, post-mortem regional analyses, and other imaging techniques. Reports concerning results in psychiatric disorders, dementias, and the effects of behaviorial tasks and pharmacological treatments are featured. We also invite manuscripts on the methods of obtaining images and computer processing of the images themselves. Selected case reports are also published.