Accuracy of 177Lu activity quantification using MCNP5-Modeled SPECT imaging

IF 1.6 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2025-03-15 DOI:10.1016/j.apradiso.2025.111786

P. Morthy , M. Musarudin , N.S. Ab Shukor , M.A. Said , D. Xianling , M.I. Saripan

{"title":"Accuracy of 177Lu activity quantification using MCNP5-Modeled SPECT imaging","authors":"P. Morthy , M. Musarudin , N.S. Ab Shukor , M.A. Said , D. Xianling , M.I. Saripan","doi":"10.1016/j.apradiso.2025.111786","DOIUrl":null,"url":null,"abstract":"<div><div>The present study was conducted to assess the accuracy of <sup>177</sup>Lu quantification using Monte Carlo N-Particle Transport Code, Version 5 MCNP5. The developed code was verified against calibration factor (CF) measured experimentally. The CF for converting SPECT data into units of activity concentration was determined by modeling two phantom configurations: (1) a uniform <sup>177</sup>Lu concentration of 5.3600 ± 0.0005 MBq/mL in 20 mL Petri dish, resulting in a CF<sub>1</sub> of 12.5 ± 1.5 cps/MBq, and (2) a 65.4 mL radioactive sphere (5.0 cm diameter) within a non-radioactive background in a cylindrical Jaszczak phantom, yielding a CF<sub>2</sub> of 16.0 ± 2.0 cps/MBq. The significant difference between CF<sub>1</sub> and CF<sub>2</sub> (21.26 %) highlights the impact of phantom size and geometry on the calibration process. The quantification error was evaluated using recovery coefficient (RC) of the spherical inserts in a NEMA phantom. The established CFs and RCs provide a reliable framework for accurate activity quantification in <sup>177</sup>Lu SPECT imaging using the established MCNP5 code. Our findings suggest that MCNP5 simulations can effectively model the SPECT imaging process, accounting for factors such as photon attenuation and scatter, offering the potential for improved dosimetry calculations in radionuclide therapy.</div></div>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"220 ","pages":"Article 111786"},"PeriodicalIF":1.6000,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Radiation and Isotopes","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0969804325001319","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}

引用次数: 0

Abstract

The present study was conducted to assess the accuracy of ¹⁷⁷Lu quantification using Monte Carlo N-Particle Transport Code, Version 5 MCNP5. The developed code was verified against calibration factor (CF) measured experimentally. The CF for converting SPECT data into units of activity concentration was determined by modeling two phantom configurations: (1) a uniform ¹⁷⁷Lu concentration of 5.3600 ± 0.0005 MBq/mL in 20 mL Petri dish, resulting in a CF₁ of 12.5 ± 1.5 cps/MBq, and (2) a 65.4 mL radioactive sphere (5.0 cm diameter) within a non-radioactive background in a cylindrical Jaszczak phantom, yielding a CF₂ of 16.0 ± 2.0 cps/MBq. The significant difference between CF₁ and CF₂ (21.26 %) highlights the impact of phantom size and geometry on the calibration process. The quantification error was evaluated using recovery coefficient (RC) of the spherical inserts in a NEMA phantom. The established CFs and RCs provide a reliable framework for accurate activity quantification in ¹⁷⁷Lu SPECT imaging using the established MCNP5 code. Our findings suggest that MCNP5 simulations can effectively model the SPECT imaging process, accounting for factors such as photon attenuation and scatter, offering the potential for improved dosimetry calculations in radionuclide therapy.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.