Gender disparity in quality of life in patients with atrial fibrillation during the Syrian conflict: An observational cohort study

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart Rhythm O2 Pub Date : 2025-03-01 DOI:10.1016/j.hroo.2024.12.010

Ibrahim Antoun PhD , Alkassem Alkhayer MSc , Aref Jalal Eldin MD , Alamer Alkhayer MD , Khaled Yazji FRCP , Riyaz Somani PhD , G. André Ng PhD , Mustafa Zakkar PhD

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Abstract

Background

The EuroQoL 5 dimensions is the first validated questionnaire to assess quality of life (QoL) in patients with atrial fibrillation (AF) in Syria.

Objective

This study aimed to evaluate the gender disparity in QoL in Syrian patients with AF during the ongoing conflict.

Methods

The study involved patients admitted to the emergency department of Tishreen University Hospital in Latakia, Syria, with AF as the primary diagnosis between June 2023 and June 2024. Arabic versions of the EuroQoL 5 dimensions were administered to patients on admission, and their demographic data were taken from their medical notes.

Results

A total of 406 satisfied the study criteria, of whom 180 (44%) were males; and the median age was 67 (57- 73) years. Compared with men, women had more congestive cardiac failure (CCF) (32% vs 22%; P=.001) and were more uneducated (48% vs 27%; P<.001). Females demonstrated poorer QoL across all scoring dimensions (activities: 2.4 vs 1.7; mobility: 2.5 vs 1.6; self-care: 2.6 vs 1.8; pain: 2.6 vs 1.7; anxiety: 2.9 vs 1.8; EuroQol Visual Analogue Scale: 49.8 vs 79.8), all of which had P<.001. Multivariable logistic regression demonstrated that women (odds ratio [OR]: 5.2; 95% confidence interval [CI] 2.2–7.6; P<.001 and OR 6.2; 95% CI 3.1–9.7; P<.001) and CCF (OR 3.3; 95% CI 1.5–6.9; P<.001 and OR 4.2; 95% CI 2.2–7.3; P<.001) were independently associated with poor QoL.

Conclusion

Syrian women admitted with AF had poorer QoL than did their men counterparts. CCF and female sex were independent predictors of poor QoL.

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叙利亚冲突期间房颤患者生活质量的性别差异：一项观察性队列研究

EuroQoL 5维度是叙利亚第一个评估心房颤动（AF）患者生活质量（QoL）的有效问卷。目的本研究旨在评估叙利亚冲突期间房颤患者生活质量的性别差异。方法该研究纳入了2023年6月至2024年6月期间在叙利亚拉塔基亚Tishreen大学医院急诊科收治的以房颤为主要诊断的患者。入院时对患者使用阿拉伯语版本的EuroQoL 5维度，其人口统计数据取自其医疗记录。结果406例患者符合研究标准，其中男性180例（44%）；中位年龄为67岁（57 ~ 73岁）。与男性相比，女性有更多的充血性心力衰竭（CCF） (32% vs 22%；P=.001)，受教育程度更高(48% vs 27%；术;措施)。女性在所有得分维度上都表现出较差的生活质量(活动：2.4 vs 1.7；机动性：2.5 vs 1.6；自我照顾：2.6 vs 1.8；疼痛：2.6 vs 1.7；焦虑：2.9 vs 1.8；EuroQol视觉模拟量表：49.8比79.8)，均为P<； 0.001。多变量logistic回归显示女性(优势比[OR]: 5.2；95%置信区间[CI] 2.2-7.6；术;。001和OR 6.2；95% ci 3.1-9.7；P<.001)和CCF (OR 3.3；95% ci 1.5-6.9；术;。001和OR 4.2；95% ci 2.2-7.3；P<.001)与较差的生活质量独立相关。结论叙利亚女性房颤患者的生活质量较男性差。CCF和女性性别是不良生活质量的独立预测因子。

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