The role of membrane-biomolecular condensate interactions in stress

Abstract

Biomolecules can be condensed through liquid-liquid phase separation (LLPS) or other material states. The resulting biomolecular condensates can play key roles in cellular organisation and stress responses. While often regarded as membrane-less structures, some biomolecular condensates interact with cellular membranes. Despite their potential importance, these interactions remain largely unexplored, primarily due to their dynamic nature. We focus here on membrane-biomolecular condensate interactions that have significant functions in stress responses, suggesting their link with long-term stress adaption.