Ginkgo biloba leaf extract EGb 761® for the treatment of various diseases: Overview of systematic reviews

IF 6.7 1区医学 Q1 CHEMISTRY, MEDICINAL

Phytomedicine Pub Date : 2025-03-07 DOI:10.1016/j.phymed.2025.156565

Katrin Pfuhlmann , Anna K. Koch , Jost Langhorst

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引用次数: 0

Abstract

Background

Ginkgo biloba leaf extract EGb 761® might have diverse therapeutic effects.

Objective

We conducted an overview of systematic reviews (SRs) to compile the efficacy and safety of EGb 761®.

Methods

The Cochrane Database of Systematic Reviews, MEDLINE (via PubMed), Embase (via OVID) and PROSPERO were searched from inception until July 25th, 2023 with an update on January 30th, 2025. SRs were included if they evaluated the efficacy and safety of oral treatment with EGb 761® under any clinical condition or in healthy subjects for clinical reasons, such as prevention, or for health promotion. Two authors carried out screening, selection, data extraction and risk of bias assessment (AMSTAR 2). The degree of overlap was quantified. The overview was registered a priori (PROSPERO: CRD42023423789).

Results

We screened 126 articles and included reviews on neurocognitive disorders (n = 13), tinnitus, macular degeneration and schizophrenia (all n = 1). For neurocognitive disorders, most SRs were in favor of EGb 761® regarding cognition and behavioral and/or psychological symptoms, while the results for functional activities of daily living varied. EGb 761® might have positive effects on tinnitus, macular degeneration or schizophrenia: however, more evidence is needed. In general, EGb 761® appears to be safe. Methodological quality was poor in all SRs. The overall overlap of the primary studies on neurocognitive disorders was very high, and pairwise overlap varied.

Conclusion

EGb 761® has been studied in various reviews, particularly regarding neurocognitive disorders and has been reported to be safe in many SRs. The results must be treated with caution due to the poor quality of the SRs.

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来源期刊

Phytomedicine 医学-药学

CiteScore

10.30

自引率

5.10%

发文量

670

审稿时长

91 days

期刊介绍： Phytomedicine is a therapy-oriented journal that publishes innovative studies on the efficacy, safety, quality, and mechanisms of action of specified plant extracts, phytopharmaceuticals, and their isolated constituents. This includes clinical, pharmacological, pharmacokinetic, and toxicological studies of herbal medicinal products, preparations, and purified compounds with defined and consistent quality, ensuring reproducible pharmacological activity. Founded in 1994, Phytomedicine aims to focus and stimulate research in this field and establish internationally accepted scientific standards for pharmacological studies, proof of clinical efficacy, and safety of phytomedicines.