Dynamic hydrogels for biofabrication: A review

IF 12.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Biomaterials Pub Date : 2025-03-18 DOI:10.1016/j.biomaterials.2025.123266

Runze Xu , Hon Son Ooi , Liming Bian , Liliang Ouyang , Wei Sun

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引用次数: 0

Abstract

Reversibly crosslinked dynamic hydrogels have emerged as a significant material platform for biomedical applications owing to their distinctive time-dependent characteristics, including shear-thinning, self-healing, stress relaxation, and creep. These physical properties permit the use of dynamic hydrogels as injectable carriers or three-dimensional printable bioinks. It is noteworthy that matrix dynamics can serve as physical cues that stimulate cellular processes. Therefore, dynamic hydrogels are preferred for tissue engineering and biofabrication, which seek to create functional tissue constructs that require regulation of cellular processes. This review summarizes the critical biophysical properties of dynamic hydrogels, various cellular processes and related mechanisms triggered by hydrogel dynamics, particularly in three-dimensional culture scenarios. Subsequently, we present an overview of advanced biofabrication techniques, particularly 3D bioprinting, of dynamic hydrogels for the large-scale production of tissue and organ engineering models. This review presents an overview of the strategies that can be used to expand the range of applications of dynamic hydrogels in biofabrication, while also addressing the challenges and opportunities that arise in the field. This review highlights the importance of matrix dynamics in regulating cellular processes and elucidates strategies for leveraging them in the context of biofabrication.

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生物制造用动态水凝胶研究进展

可逆交联动态水凝胶由于其独特的时间相关特性，包括剪切变薄、自愈、应力松弛和蠕变，已成为生物医学应用的重要材料平台。这些物理性质允许使用动态水凝胶作为可注射载体或三维可打印的生物墨水。值得注意的是，矩阵动力学可以作为刺激细胞过程的物理线索。因此，动态水凝胶是组织工程和生物制造的首选，它们寻求创建需要调节细胞过程的功能性组织结构。本文综述了动态水凝胶的关键生物物理特性，水凝胶动力学引发的各种细胞过程和相关机制，特别是在三维培养情况下。随后，我们概述了先进的生物制造技术，特别是3D生物打印，用于大规模生产组织和器官工程模型的动态水凝胶。本文概述了可用于扩大动态水凝胶在生物制造中的应用范围的策略，同时也解决了该领域出现的挑战和机遇。这篇综述强调了基质动力学在调节细胞过程中的重要性，并阐明了在生物制造背景下利用它们的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomaterials 工程技术-材料科学：生物材料

CiteScore

26.00

自引率

2.90%

发文量

565

审稿时长

46 days

期刊介绍： Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. The scope of the journal covers the wide range of physical, biological and chemical sciences that underpin the design of biomaterials and the clinical disciplines in which they are used. These sciences include polymer synthesis and characterization, drug and gene vector design, the biology of the host response, immunology and toxicology and self assembly at the nanoscale. Clinical applications include the therapies of medical technology and regenerative medicine in all clinical disciplines, and diagnostic systems that reply on innovative contrast and sensing agents. The journal is relevant to areas such as cancer diagnosis and therapy, implantable devices, drug delivery systems, gene vectors, bionanotechnology and tissue engineering.