Bioactive coumarins from Notopterygium incisum root: A step toward natural ant-infammatory candidates

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-03-21 DOI:10.1016/j.fitote.2025.106491

Li-Shi Jiang , Hong-Xiang Li , Chuan-Yang Zhang , Yu-Ting Mu , Meng-Jiao Zhang , Yun-Jie Hu , Da-Le Guo , Yun Deng

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Abstract

Five novel coumarins (1–5) were isolated from the root of Notopterygium incisum, and their chemical structures were elucidated based on HRESIMS and NMR spectral data. The anti-inflammatory activities of compounds 1–5 were evaluated in a lipopolysaccharide-induced RAW 264.7 cell model by measuring the levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α). The results demonstrated that all five compounds exhibited significant anti-inflammatory potential. Further studies showed that compound 5 (at a concentration of 7.5–30 μM) displayed potent anti-inflammatory effects by inhibiting the expression of inflammatory mediators (COX-2, iNOS) and reducing nitric oxide (NO) production. Mechanistic studies revealed that compound 5 exerted its anti-inflammatory effects by inhibiting the NF-κB signaling pathway. These findings highlight the potential of coumarins as anti-inflammatory agents and provide a foundation for their further exploration as therapeutic candidates.

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从切牙白杨根提取的生物活性香豆素：迈向天然抗炎候选物的一步

从切牙白杨（Notopterygium incisum）根中分离到5种新型香豆素（1 ~ 5），并利用hresms和NMR光谱数据对其化学结构进行了鉴定。在脂多糖诱导的RAW 264.7细胞模型中，通过测量促炎细胞因子（IL-1β、IL-6和TNF-α）的水平来评估化合物1-5的抗炎活性。结果表明，这5种化合物均具有显著的抗炎作用。进一步的研究表明，化合物5 （7.5 ~ 30 μM）通过抑制炎症介质（COX-2、iNOS）的表达和减少一氧化氮（NO）的产生，具有较强的抗炎作用。机制研究表明，化合物5通过抑制NF-κB信号通路发挥抗炎作用。这些发现突出了香豆素作为抗炎剂的潜力，并为进一步探索其作为治疗候选药物提供了基础。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.