RBE evaluation during the vertebral and brain cancer treatment using low-kV X-rays: A hybrid simulation approach

IF 2.6 3区工程技术 Q1 NUCLEAR SCIENCE & TECHNOLOGY

Nuclear Engineering and Technology Pub Date : 2025-02-19 DOI:10.1016/j.net.2025.103552

Reza Shamsabadi, Hamid Reza Baghani, Zeynab Alvarmir

{"title":"RBE evaluation during the vertebral and brain cancer treatment using low-kV X-rays: A hybrid simulation approach","authors":"Reza Shamsabadi, Hamid Reza Baghani, Zeynab Alvarmir","doi":"10.1016/j.net.2025.103552","DOIUrl":null,"url":null,"abstract":"<div><div>Intraoperative radiotherapy (IORT) using INTRABEAM machine and specific needle applicator is a candidate modality for vertebral and brain cancer treatment. Current study aims to evaluate the relative biologic effectiveness (RBE) values of low energy X-rays emitted from the surface of needle applicator during the IORT of vertebral and brain tumors, through a hybrid Monte Carlo (MC) simulation approach.</div><div>To estimate RBE values, Geant4 was employed to simulate the INTRABEAM X-ray source along with needle applicator as well as scoring released secondary electron spectra within considered tissues. Then, RBE values were estimated by Monte Carlo damage simulation (MCDS) code.</div><div>An increasing trend of RBE<sub>DSB</sub> (RBE for DNA double strand breaks) values was found by increasing the distance from applicator surface. The maximum RBE<sub>DSB</sub> values were obtained for vertebral bone (C4) among the investigated tissues due to higher physical density and Z<sub>eff</sub> values. Cell oxygenation level also affected RBE<sub>DSB</sub> with a maximum value of 64 % when moving from 0.3 % to 4 % level.</div><div>From the results, it can be concluded that RBE values during the low energy X-ray IORT of brain and vertebral column tumors using dedicated needle applicator can be affected by considerable differences in tissue composition and cell oxygenation level.</div></div>","PeriodicalId":19272,"journal":{"name":"Nuclear Engineering and Technology","volume":"57 8","pages":"Article 103552"},"PeriodicalIF":2.6000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nuclear Engineering and Technology","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1738573325001202","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUCLEAR SCIENCE & TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Intraoperative radiotherapy (IORT) using INTRABEAM machine and specific needle applicator is a candidate modality for vertebral and brain cancer treatment. Current study aims to evaluate the relative biologic effectiveness (RBE) values of low energy X-rays emitted from the surface of needle applicator during the IORT of vertebral and brain tumors, through a hybrid Monte Carlo (MC) simulation approach.

To estimate RBE values, Geant4 was employed to simulate the INTRABEAM X-ray source along with needle applicator as well as scoring released secondary electron spectra within considered tissues. Then, RBE values were estimated by Monte Carlo damage simulation (MCDS) code.

An increasing trend of RBE_DSB (RBE for DNA double strand breaks) values was found by increasing the distance from applicator surface. The maximum RBE_DSB values were obtained for vertebral bone (C4) among the investigated tissues due to higher physical density and Z_eff values. Cell oxygenation level also affected RBE_DSB with a maximum value of 64 % when moving from 0.3 % to 4 % level.

From the results, it can be concluded that RBE values during the low energy X-ray IORT of brain and vertebral column tumors using dedicated needle applicator can be affected by considerable differences in tissue composition and cell oxygenation level.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Nuclear Engineering and Technology 工程技术-核科学技术

CiteScore

4.80

自引率

7.40%

发文量

431

审稿时长

3.5 months

期刊介绍： Nuclear Engineering and Technology (NET), an international journal of the Korean Nuclear Society (KNS), publishes peer-reviewed papers on original research, ideas and developments in all areas of the field of nuclear science and technology. NET bimonthly publishes original articles, reviews, and technical notes. The journal is listed in the Science Citation Index Expanded (SCIE) of Thomson Reuters. NET covers all fields for peaceful utilization of nuclear energy and radiation as follows: 1) Reactor Physics 2) Thermal Hydraulics 3) Nuclear Safety 4) Nuclear I&C 5) Nuclear Physics, Fusion, and Laser Technology 6) Nuclear Fuel Cycle and Radioactive Waste Management 7) Nuclear Fuel and Reactor Materials 8) Radiation Application 9) Radiation Protection 10) Nuclear Structural Analysis and Plant Management & Maintenance 11) Nuclear Policy, Economics, and Human Resource Development