Lipid-lowering effects and metabolomic investigation of Polygonatum sibiricum fermented by Lactobacillus plantarum NX-1

IF 3.7 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Process Biochemistry Pub Date : 2025-03-17 DOI:10.1016/j.procbio.2025.03.007

Wenjuan Cao , Yan Liu , Zhao Zhang , Xiaodong Xu

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Abstract

In this study, Lactobacillus plantarum NX-1 was utilized to ferment Polygonatum sibiricum. Through optimization of this process, the inhibition rate of pancreatic lipase was enhanced by 163.2 %. Further metabolomic analysis showed that the content of cholic acid metabolites such as taurocholic acid, acetylcholine, phosphocholine, linoleic acid metabolites, (+/-)12, 13-DiHOME and 13-OxoODE increased observably after fermentation, which was an important reason for its lipid-lowering effect. In the high-fat zebrafish model, the fermented Polygonatum sibiricum significantly inhibited lipid accumulation. In summary, Lactobacillus plantarum NX-1 fermentation not only increases the contents of polysaccharides and saponins in polygonatum sibiricum extract but also significantly increases the contents of taurocholic acid, acetylcholine, phosphocholine, (+/-)12, 13-DiHOME and 13-OxoODE. In addition, it can inhibit the lipid accumulation of the high-fat diet-fed zebrafish.

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来源期刊

Process Biochemistry 生物-工程：化工

CiteScore

8.30

自引率

4.50%

发文量

374

审稿时长

53 days

期刊介绍： Process Biochemistry is an application-orientated research journal devoted to reporting advances with originality and novelty, in the science and technology of the processes involving bioactive molecules and living organisms. These processes concern the production of useful metabolites or materials, or the removal of toxic compounds using tools and methods of current biology and engineering. Its main areas of interest include novel bioprocesses and enabling technologies (such as nanobiotechnology, tissue engineering, directed evolution, metabolic engineering, systems biology, and synthetic biology) applicable in food (nutraceutical), healthcare (medical, pharmaceutical, cosmetic), energy (biofuels), environmental, and biorefinery industries and their underlying biological and engineering principles.