Notch1 is essential for maintaining adult SVZ neurogenic niche and its knockout leads to aberrant neurogenesis and fine olfactory dysfunction

IF 1 Q4 GENETICS & HEREDITY

Gene Reports Pub Date : 2025-03-18 DOI:10.1016/j.genrep.2025.102200

Vadakkath Meera , Suresh Surya , Surendran Parvathy , Nair Pradeep Jyothi , Paul Ann Riya , Biju Surendran Nair , Jackson James

引用次数: 0

Abstract

The notch signaling pathway and its effector molecules are crucial for maintaining neural stem cells (NSCs) in the adult brain's sub-ventricular zone (SVZ). However, studies are lacking in exploring the functional consequences of knocking out Notch1 from the NSCs in the SVZ. Here we show that the number of actively dividing NSCs increases in the SVZ of the Notch1 conditional knockouts, which subsequently generates newborn neurons in the olfactory bulb. In addition the Notch1 conditional knockout has deficits in discrimination of two nonsocial odorants (geraniol and eugenol), but other olfactory functioning remains unaffected. Altogether, our study demonstrates the role of Notch1 in maintaining NSCs in the SVZ and the effect of subsequent altered neurogenesis on olfactory functions.

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来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.