Combination of ultrasound and supercritical carbon dioxide extraction for trigonelline production from Quisqualis indica

IF 8.7 1区化学 Q1 ACOUSTICS

Ultrasonics Sonochemistry Pub Date : 2025-03-18 DOI:10.1016/j.ultsonch.2025.107317

Xing-Yu Liu , Yin-Long Li , Hai-Tao Zhang , Jing Zuo , Hans Gregersen , Hong Ou

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Abstract

Trigonelline is a natural alkaloid with important nutrient benefits. A hybrid technique adopting ultrasound-assisted supercritical CO₂ extraction (UASCE) was exploited for extraction of trigonelline from Quisqualis indica. Response surface methodology was used to optimize operational parameters of the UASCE process, which indicated that the highest trigonelline yield (TY), 4.22 ± 0.06 mg/g dry mass, reached at 62 °C temperature, 26 MPa pressure, 13.5 wt% co-solvent concentration, and 0.16 W/mL ultrasonic energy density. When compared to traditional supercritical CO₂ extraction, UASCE yielded higher TY more quickly while using milder operational conditions and producing higher antioxidant capacity and concentrations of phytochemicals (alkaloids, flavonoids, triterpenoids) of the extract. Microstructural observation showed that the extensive micro-fractures formed in UASCE-processed samples may have positive effects on solutes liberation. Furthermore, a kinetic study revealed that the developed Sovová models matched with the measured results. The extraction impetus was derived primarily from convection mechanism. Ultrasound increased extraction rates and mass transfer coefficients and shortened the characteristic extraction periods. Additionally, a correlated Chrastil equation was developed for determination of solubility under varying extraction conditions. The Chrastil model reflected actual solubilities of trigonelline satisfactorily and a typical crossover solubility phenomenon was observed. Ultrasound can effectively promote the solubility of trigonelline in supercritical CO₂. In conclusion, UASCE is a sustainable and high-performance procedure to produce high-quality trigonelline-rich extracts. This paper provides new work about industrial production design of trigonelline for the future. Furthermore, Quisqualis indica serves as a prospective natural source for trigonelline acquisition.

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超声与超临界二氧化碳联合萃取法生产葫芦巴碱

葫芦巴碱是一种具有重要营养价值的天然生物碱。采用超声辅助超临界CO2萃取（UASCE）的混合萃取技术，对芦笋中的葫芦巴碱进行了提取。利用响应面法对UASCE工艺参数进行优化，结果表明，在温度62℃、压力26 MPa、共溶剂浓度13.5 wt%、超声能量密度0.16 W/mL的条件下，trigonelline产率最高，为4.22±0.06 mg/g干质量。与传统的超临界CO2萃取相比，UASCE在更温和的操作条件下更快地获得更高的TY，并产生更高的抗氧化能力和提取物的植物化学物质（生物碱、黄酮类化合物、三萜）浓度。显微组织观察表明，uasce处理样品中形成的广泛的微断裂可能对溶质的释放有积极的影响。此外，动力学研究表明，所建立的sovov模型与实测结果相吻合。抽提动力主要来源于对流机制。超声提高了提取率和传质系数，缩短了特征提取周期。此外，建立了一个相关的Chrastil方程来测定不同提取条件下的溶解度。该模型较好地反映了葫芦巴碱的实际溶解度，并观察到典型的交叉溶解度现象。超声能有效促进葫芦巴碱在超临界CO2中的溶解度。综上所述，UASCE是一种可持续、高效的工艺，可生产高品质的富含葫芦巴碱的提取物。为今后葫芦巴碱的工业生产设计提供了新的思路。此外，藜麦是葫芦巴碱获得的潜在天然来源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasonics Sonochemistry 化学-化学综合

CiteScore

15.80

自引率

11.90%

发文量

361

审稿时长

59 days

期刊介绍： Ultrasonics Sonochemistry stands as a premier international journal dedicated to the publication of high-quality research articles primarily focusing on chemical reactions and reactors induced by ultrasonic waves, known as sonochemistry. Beyond chemical reactions, the journal also welcomes contributions related to cavitation-induced events and processing, including sonoluminescence, and the transformation of materials on chemical, physical, and biological levels. Since its inception in 1994, Ultrasonics Sonochemistry has consistently maintained a top ranking in the "Acoustics" category, reflecting its esteemed reputation in the field. The journal publishes exceptional papers covering various areas of ultrasonics and sonochemistry. Its contributions are highly regarded by both academia and industry stakeholders, demonstrating its relevance and impact in advancing research and innovation.