Injectable, self-healing and antioxidative gelatin-based nanocomposite hydrogels accelerating full-thickness wound healing

IF 5.8 2区化学 Q1 POLYMER SCIENCE

European Polymer Journal Pub Date : 2025-03-18 DOI:10.1016/j.eurpolymj.2025.113901

Caiyuan Wang , Yangyang Guo , Honghong Zhang , Cuifang Wu , Xinping Wang , Anlian Wei , Liang Hong , Lijing Teng , Zhu Zeng

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引用次数: 0

Abstract

Injectable, multifunctional wound dressings hold great potential for treating severe dermal wounds with irregular shapes or cavities. Here, we developed an injectable nanocomposite hydrogel by incorporating polydopamine functionalized Laponite® (PDA@LAP) into a thermosensitive gelatin supramolecular polymer through a combination of physical and chemical crosslinking. This injectable and self-healing nanocomposite hydrogel, denoted as PLG, exhibits excellent physiological stability, biocompatibility, hemostasis and specific antioxidant activity. In a rat full-thickness wound model, PLG significantly enhanced wound healing by promoting collagen deposition, highlighting its potential as a wound dressing for irregular skin lesions without causing secondary damage. Our findings suggest that these multifunctional properties make PLG an ideal candidate for minimally invasive treatment of full-thickness wounds in clinical applications.

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来源期刊

European Polymer Journal 化学-高分子科学

CiteScore

9.90

自引率

10.00%

发文量

691

审稿时长

23 days

期刊介绍： European Polymer Journal is dedicated to publishing work on fundamental and applied polymer chemistry and macromolecular materials. The journal covers all aspects of polymer synthesis, including polymerization mechanisms and chemical functional transformations, with a focus on novel polymers and the relationships between molecular structure and polymer properties. In addition, we welcome submissions on bio-based or renewable polymers, stimuli-responsive systems and polymer bio-hybrids. European Polymer Journal also publishes research on the biomedical application of polymers, including drug delivery and regenerative medicine. The main scope is covered but not limited to the following core research areas: Polymer synthesis and functionalization • Novel synthetic routes for polymerization, functional modification, controlled/living polymerization and precision polymers. Stimuli-responsive polymers • Including shape memory and self-healing polymers. Supramolecular polymers and self-assembly • Molecular recognition and higher order polymer structures. Renewable and sustainable polymers • Bio-based, biodegradable and anti-microbial polymers and polymeric bio-nanocomposites. Polymers at interfaces and surfaces • Chemistry and engineering of surfaces with biological relevance, including patterning, antifouling polymers and polymers for membrane applications. Biomedical applications and nanomedicine • Polymers for regenerative medicine, drug delivery molecular release and gene therapy The scope of European Polymer Journal no longer includes Polymer Physics.