Characterization of real-time dose measurement using monitor ionization chamber in electron beam FLASH radiotherapy

IF 2.6 3区工程技术 Q1 NUCLEAR SCIENCE & TECHNOLOGY

Nuclear Engineering and Technology Pub Date : 2025-02-19 DOI:10.1016/j.net.2025.103551

Xinle Lang , Faming Luo , Min Li , Kai Zhou , Juan Li , Zhenguo Hu , Ruishi Mao , Zhiguo Xu , Guoqing Xiao

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引用次数: 0

Abstract

FLASH radiotherapy (RT) reduces the level of irradiation damage to normal tissue by utilizing an ultra-high dose rate to deliver the dose into the tumor target area in millisecond-order time. The ultra-high dose rate (≥40 Gy/s) renders existing online dose monitors largely ineffective or dose-rate dependent. In this study, the dose distribution based on a 9 MeV ultra-high dose rate electron beam FLASH irradiation platform was investigated using Gafchromic EBT3 film, and its flatness deviation within ±5 % and symmetry deviation within ±3 % meets the standard requirements. We also explored the saturation effect observed in ionization chambers (IC) used for online monitoring by reducing the sensitive volume of the chamber and its air pressure. Real-time dose monitoring was successfully achieved with the electron beam at a source skin distance (SSD) of 100 cm and a dose rate of 250 Gy/s, demonstrating a linearity deviation within ±2 %. The IC correction factor was calculated according to the IAEA TRS-398 standard. In conclusion, this study successfully established quality assurance for electron beam irradiation at ultra-high dose rates using Gafchromic EBT3 film and enabled effective online dose monitoring. This work provides a dosimetric foundation for future scientific research and clinical applications of FLASH RT.

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来源期刊

Nuclear Engineering and Technology 工程技术-核科学技术

CiteScore

4.80

自引率

7.40%

发文量

431

审稿时长

3.5 months

期刊介绍： Nuclear Engineering and Technology (NET), an international journal of the Korean Nuclear Society (KNS), publishes peer-reviewed papers on original research, ideas and developments in all areas of the field of nuclear science and technology. NET bimonthly publishes original articles, reviews, and technical notes. The journal is listed in the Science Citation Index Expanded (SCIE) of Thomson Reuters. NET covers all fields for peaceful utilization of nuclear energy and radiation as follows: 1) Reactor Physics 2) Thermal Hydraulics 3) Nuclear Safety 4) Nuclear I&C 5) Nuclear Physics, Fusion, and Laser Technology 6) Nuclear Fuel Cycle and Radioactive Waste Management 7) Nuclear Fuel and Reactor Materials 8) Radiation Application 9) Radiation Protection 10) Nuclear Structural Analysis and Plant Management & Maintenance 11) Nuclear Policy, Economics, and Human Resource Development