Ag(I)-Catalyzed Intramolecular Cascade Cyclization to Construct [6–5–7–6] Heterotetracyclic (-N and -O) Indole Fused Scaffolds

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-03-24 DOI:10.1002/adsc.202500140

Madan Kumar, Ankush Kumar, Soni Devi, Avijit Goswami

引用次数: 0

Abstract

Herein, we report a silver-catalyzed intramolecular cascade reaction of 2-alkynylaniline tethered heteroenone systems to achieve the synthesis of [6–5–7–6] heterotetracyclic indole fused benzoxepino- and benzoazepino scaffolds. The reaction proceeded through a silver(I)-initiation cascade intramolecular 5-endo-dig cyclization followed by 7-exo-trig cyclization to enable the structurally diverse [6–5–7–6] heterotetracyclic adducts in modest to good yields.

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在此，我们报告了一种银催化的 2-炔基苯胺系杂烯酮体系分子内级联反应，以实现[6-5-7-6] 杂四环吲哚融合苯并氧杂卓和苯并氮杂卓支架的合成。该反应通过银（I）引发的分子内 5-endo-dig 级联环化反应进行，然后是 7-exo-trig 环化反应，从而获得了结构多样的 [6-5-7-6] 杂四环加合物，产率从中等到良好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.