Longitudinal Associations Between Peritraumatic Oestradiol and Fear Responding in Women and Men.

IF 3 2区心理学 Q2 PSYCHIATRY

Stress and Health Pub Date : 2025-04-01 DOI:10.1002/smi.3522

Robyn A Ellis, Theresa K Webber, Natalie C Noble, Sarah D Linnstaedt, Rebecca Hinrichs, Charis Wiltshire, Mariam H Reda, William Davie, Stacey L House, Francesca L Beaudoin, Xinming An, Thomas C Neylan, Gari D Clifford, Laura T Germine, Scott L Rauch, John P Haran, Alan B Storrow, Christopher Lewandowski, Paul I Musey, Phyllis L Hendry, Sophia Sheikh, Brittany E Punches, Jose L Pascual, Mark J Seamon, Elizabeth M Datner, Claire Pearson, David A Peak, Robert M Domeier, Niels K Rathlev, Brian J O'Neil, Paulina Sergot, Leon D Sanchez, Steven E Bruce, Jutta Joormann, Ronald C Kessler, Kerry J Ressler, Karestan C Koenen, Samuel A McLean, Jennifer S Stevens, Tanja Jovanovic, Antonia V Seligowski

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引用次数: 0

Abstract

PTSD is more prevalent in women than men and associated with autonomic dysfunction. Higher oestradiol levels have been associated with decreased PTSD severity, however, the impact of oestradiol on autonomic function is not well characterised. We examined associations among peritraumatic oestradiol levels and autonomic function in the multi-site AURORA study. Participants (n = 283, 69.6% female) were recruited from the emergency department (ED) following trauma exposure. Skin conductance (SC) was measured during trauma recall at the ED. Oestradiol was assayed from blood collected at ED, 2-week and 6-month. Fear conditioning, including fear potentiated startle (FPS), was completed at 2-week and 6-month. In women, ED oestradiol was significantly positively associated with ED SC and FPS at 6-month. In men, significant negative correlations between ED oestradiol and SC were found. Among women in the study, peritraumatic oestradiol was positively associated with fear responding 6-month. Findings suggest that the protective effects of oestradiol on PTSD may depend on other factors, such as time since trauma. Additional research is needed to elucidate how peritraumatic oestradiol and autonomic function may interact to confer risk for PTSD.

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创伤周围雌二醇与女性和男性恐惧反应的纵向关联。

创伤后应激障碍在女性中比男性更普遍，并与自主神经功能障碍有关。较高的雌二醇水平与创伤后应激障碍严重程度的降低有关，然而，雌二醇对自主神经功能的影响尚未得到很好的表征。我们在多位点AURORA研究中检查了创伤周围雌二醇水平和自主神经功能之间的关系。参与者（n = 283, 69.6%为女性）从创伤暴露后的急诊科（ED）招募。在ED时测量创伤回忆时的皮肤电导（SC）。在ED时、2周和6个月时采集的血液中测定雌二醇。恐惧条件反射，包括恐惧增强惊吓（FPS），分别在2周和6个月时完成。在女性中，ED雌二醇与6个月时ED SC和FPS显著正相关。在男性中，ED雌二醇与SC呈显著负相关。在研究中的女性中，创伤周围雌二醇与6个月后的恐惧反应呈正相关。研究结果表明，雌二醇对创伤后应激障碍的保护作用可能取决于其他因素，如创伤后的时间。需要进一步的研究来阐明创伤周围雌二醇和自主神经功能如何相互作用以增加PTSD的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stress and Health 医学-精神病学

CiteScore

6.40

自引率

4.90%

发文量

审稿时长

>12 weeks

期刊介绍： Stress is a normal component of life and a number of mechanisms exist to cope with its effects. The stresses that challenge man"s existence in our modern society may result in failure of these coping mechanisms, with resultant stress-induced illness. The aim of the journal therefore is to provide a forum for discussion of all aspects of stress which affect the individual in both health and disease. The Journal explores the subject from as many aspects as possible, so that when stress becomes a consideration, health information can be presented as to the best ways by which to minimise its effects.