{"title":"The high-quality chromosome-level genome assembly of Dracocephalum rupestre Hance.","authors":"Qian Zhao, Zixu Fan, Hui Yu, Zhanli Wang","doi":"10.1038/s41597-025-04778-3","DOIUrl":null,"url":null,"abstract":"<p><p>Dracocephalum rupestre Hance is China's traditional herbal medicine in the family Labiatae with numerous health benefits, including anti-inflammatory, antiviral and anti-tumor activities. However, the genus Dracocephalum has no reference genome currently, which restricts the research on the breeding, cultivation and exploration of medicinal properties in D. rupestre. Thus, we present the high-quality chromosome-level genome assembly of D. rupestre using a combination of Pacbio HiFi sequencing and Hi-C scaffolding technologies. The final genome was 435.45 Mb with a contig N50 of 49.83 Mb and a scaffold N50 of 59.06 Mb. The assembled sequences were anchored to 7 chromosomes with an integration efficiency of 96.96%. Furthermore, we predicted 25,865 protein-coding genes, 98.23% of which were functionally annotated. These results offer valuable resources for understanding the genetic basis of the unique phenotypes of D. rupestre and will facilitate further study of the functional genomics of this species.</p>","PeriodicalId":21597,"journal":{"name":"Scientific Data","volume":"12 1","pages":"472"},"PeriodicalIF":5.8000,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928585/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scientific Data","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1038/s41597-025-04778-3","RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Dracocephalum rupestre Hance is China's traditional herbal medicine in the family Labiatae with numerous health benefits, including anti-inflammatory, antiviral and anti-tumor activities. However, the genus Dracocephalum has no reference genome currently, which restricts the research on the breeding, cultivation and exploration of medicinal properties in D. rupestre. Thus, we present the high-quality chromosome-level genome assembly of D. rupestre using a combination of Pacbio HiFi sequencing and Hi-C scaffolding technologies. The final genome was 435.45 Mb with a contig N50 of 49.83 Mb and a scaffold N50 of 59.06 Mb. The assembled sequences were anchored to 7 chromosomes with an integration efficiency of 96.96%. Furthermore, we predicted 25,865 protein-coding genes, 98.23% of which were functionally annotated. These results offer valuable resources for understanding the genetic basis of the unique phenotypes of D. rupestre and will facilitate further study of the functional genomics of this species.
期刊介绍：
Scientific Data is an open-access journal focused on data, publishing descriptions of research datasets and articles on data sharing across natural sciences, medicine, engineering, and social sciences. Its goal is to enhance the sharing and reuse of scientific data, encourage broader data sharing, and acknowledge those who share their data.
The journal primarily publishes Data Descriptors, which offer detailed descriptions of research datasets, including data collection methods and technical analyses validating data quality. These descriptors aim to facilitate data reuse rather than testing hypotheses or presenting new interpretations, methods, or in-depth analyses.
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