Association of the remnant cholesterol to high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients.

IF 3.9 2区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Zebin Wang, Sibing Huang, Na Tian, Qingdong Xu, Xiaojiang Zhan, Fenfen Peng, Xiaoyang Wang, Ning Su, Xiaoran Feng, Xingming Tang, Xianfeng Wu, Qian Zhou, Jianbo Liang, Jiao Li, Yueqiang Wen
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引用次数: 0

Abstract

Background: In individuals receiving continuous ambulatory peritoneal dialysis (CAPD), remnant cholesterol (RC) and high-density lipoprotein cholesterol (HDL-C) levels significantly influence clinical outcomes. Current clinical practice might benefit from assessing these two lipid markers in combination when evaluating cardiovascular disease (CVD) and all-cause mortality. Therefore, this research sought to examine how the RC/HDL-C ratio correlates with both CVD and all-cause mortality rates among individuals receiving CAPD treatment.

Methods: Between January 1, 2005 and December 31, 2016, a multi-center retrospective analysis of 2006 CAPD patients from five peritoneal dialysis hospitals in China was conducted. Participants were split into two subgroups in accordance with the baseline serum RC/HDL-C ratio restricted cubic spline cutoff value. The correlations between mortality and RC/HDL-C ratio were examined through case-specific hazard modeling.

Results: The observation period documented 549 all-cause fatalities, with cardiovascular deaths accounting for 269 cases. The Kaplan-Meier analysis revealed statistically significant divergence in both all-cause mortality (log rank test P < 0.001) and CVD mortality (log rank test P = 0.003). Elevated RC/HDL-C ratios showed increased hazard ratios (HR) for all-cause mortality (1.335, 95% CI, 1.112-1.603, P = 0.002) and CVD mortality (1.319, 95% CI, 1.013-1.717, P = 0.040) compared to lower ratio counterparts. Nevertheless, no statistically meaningful association was found between CVD mortality and either RC (HR: 1.296, 95% CI, 0.992-1.691, P = 0.057) or HDL-C (HR: 0.887, 95% CI, 0.680-1.157, P = 0.376).

Conclusion: The RC/HDL-C ratio independently predicts mortality in CAPD patients, persisting as a significant prognostic marker after multivariable adjustment.

腹膜透析患者残余胆固醇与高密度脂蛋白胆固醇比率与死亡率的关系。
背景:在接受持续非卧床腹膜透析(CAPD)的患者中,残余胆固醇(RC)和高密度脂蛋白胆固醇(HDL-C)水平对临床结果有显著影响。在评估心血管疾病(CVD)和全因死亡率时,将这两种血脂指标结合起来进行评估可能会使目前的临床实践受益匪浅。因此,本研究试图探讨在接受 CAPD 治疗的患者中,RC/HDL-C 比值与心血管疾病和全因死亡率的相关性:方法:2005 年 1 月 1 日至 2016 年 12 月 31 日期间,对中国五家腹膜透析医院的 2006 名 CAPD 患者进行了多中心回顾性分析。根据基线血清 RC/HDL-C 比值的限制性三次样条截断值,将参与者分为两个亚组。通过病例特异性危险模型研究了死亡率与 RC/HDL-C 比率之间的相关性:观察期间共记录了549例全因死亡病例,其中心血管死亡病例为269例。卡普兰-梅耶尔分析显示,两种全因死亡率在统计学上存在显著差异(对数秩检验 P 结论):RC/HDL-C比值可独立预测CAPD患者的死亡率,经多变量调整后仍是一个重要的预后指标。
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来源期刊
Lipids in Health and Disease
Lipids in Health and Disease 生物-生化与分子生物学
CiteScore
7.70
自引率
2.20%
发文量
122
审稿时长
3-8 weeks
期刊介绍: Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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