Association of potentially inappropriate medications with frailty and frailty components in community-dwelling older women in Japan: The Otassha Study.

Abstract

Aim: The use of potentially inappropriate medications (PIMs) in older adults can increase the risk of drug-related adverse events. We aimed to examine the associations between PIMs, frailty, and each frailty component in community-dwelling older women.

Methods: This cross-sectional study included participants aged ≥65 years from a prospective cohort of older Japanese women. Frailty was classified using the Japanese version of Fried's Frailty Criteria, comprising five components. PIMs were identified using a screening tool for Japanese among regular prescription medications collected from participants' prescription notebooks. Multivariable logistic regression models adjusted for age and comorbidities were used to examine the association between PIMs (0, 1, 2, ≥3), frailty, and each component. The possible interactions between age groups (65-74 and ≥75 years) and PIMs were investigated. Age-stratified analyses were also performed.

Results: We analyzed 530 older women (median age [interquartile range], 71 [68, 75] years) with a frailty prevalence of 5.5%. Three or more PIMs were associated with frailty and weight loss (adjusted odds ratio [95% confidence interval], 3.80 [1.23, 11.80], 2.53 [1.15, 5.39]). In age-stratified analyses, ≥3 PIMs were associated with weight loss (8.39 [1.79, 48.98]) in women aged ≥75 years, whereas 1 or 2 PIMs were associated with frailty (4.52 [1.17, 19.08]) or weakness (3.13 [1.22, 7.78]) in those aged 65-74 years.

Conclusions: Our results may suggest that the number of PIM prescriptions is associated with frailty and frailty components in older women. Longitudinal studies are required to clarify the causality between the number of PIMs and frailty. Geriatr Gerontol Int 2025; ••: ••-••.