A dual-functional fluorescent probe for biosystem imaging and food safety monitoring of HSO₃^- with high selectivity and sensitivity.

IF 3.8 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Analytical and Bioanalytical Chemistry Pub Date : 2025-03-22 DOI:10.1007/s00216-025-05837-9

Yumeng Li, Ran Chen, Juanjuan Lv, Jiali Su, Mengxu Gao, Kaifu Ma, Xiupei Cheng, Wei Shu

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引用次数: 0

Abstract

In the food field, HSO₃^- is commonly used as a beverage additive, antioxidant, enzyme inhibitor, and preservative to extend shelf life and freshness. However, excessive intake of exogenous HSO₃^- can lead to abnormal HSO₃^- concentration levels in the body, causing cardiovascular and respiratory diseases. This highlights the urgent need to develop a rapid and sensitive probe for the quantitative detection of HSO₃^- in foods and biosystems. In this study, we design and synthesize a novel HSO₃^- fluorescent probe named DCPD. Bioimaging experiments show that DCPD has good mitochondrial targeting and can be used to imaging the redox process of HSO₃^-/H₂O₂ in cells and tissue. In addition, DCPD has been used in detecting HSO₃^- in foods with satisfactory recoveries (98.62-105.06%), further demonstrating its compatibility and utility. Thus, the DCPD probe offers substantial promise for application in food analysis and the assessment of HSO₃^- concentrations in biological systems.

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来源期刊

Analytical and Bioanalytical Chemistry 化学-分析化学

CiteScore

8.00

自引率

4.70%

发文量

638

审稿时长

2.1 months

期刊介绍： Analytical and Bioanalytical Chemistry’s mission is the rapid publication of excellent and high-impact research articles on fundamental and applied topics of analytical and bioanalytical measurement science. Its scope is broad, and ranges from novel measurement platforms and their characterization to multidisciplinary approaches that effectively address important scientific problems. The Editors encourage submissions presenting innovative analytical research in concept, instrumentation, methods, and/or applications, including: mass spectrometry, spectroscopy, and electroanalysis; advanced separations; analytical strategies in “-omics” and imaging, bioanalysis, and sampling; miniaturized devices, medical diagnostics, sensors; analytical characterization of nano- and biomaterials; chemometrics and advanced data analysis.