New intraocular lens containing a drug delivery system (IOL-DDS) loaded with dexamethasone

IF 3 4区医学 Q3 ENGINEERING, BIOMEDICAL

Biomedical Microdevices Pub Date : 2025-03-24 DOI:10.1007/s10544-025-00743-4

Brenda F. M. Castro, Raquel G. Arribada, Thomas T. Inoue, Elias R. Filho, Bruno C. Sena, Luiz F. L. Ferreira, Silvia L. Fialho, Armando Silva-Cunha

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引用次数: 0

Abstract

This study demonstrates the development of polymeric PLGA (50:50) nanoparticles containing dexamethasone acetate, which are dispersed in a PVA film and added to hydrophobic intraocular lenses (IOL) exclusively designed for this application. The resulting IOL-drug delivery system (IOL-DDS) can be introduced into the eye with syringe-type injectors and standard surgical techniques. The obtained results showed that the lens design does not compromise stability within the eye or weaken the loops, preserves its optical zone, and maintains injector’s functionality during surgery. The IOL-DDS releases the drug in vivo for 7 days within the therapeutic concentration range. Short-term assessment confirms the safety of the developed device for ocular structures, which is supported by slit lamp observations, intraocular pressure measurements, optical coherence tomography, and histological analysis. Minor changes in specular microscopy parameters are observed and may be related to the use of IOL and surgical instruments designed for human eyes in smaller rabbit eyes.

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来源期刊

Biomedical Microdevices 工程技术-工程：生物医学

CiteScore

6.90

自引率

3.60%

发文量

审稿时长

6 months

期刊介绍： Biomedical Microdevices: BioMEMS and Biomedical Nanotechnology is an interdisciplinary periodical devoted to all aspects of research in the medical diagnostic and therapeutic applications of Micro-Electro-Mechanical Systems (BioMEMS) and nanotechnology for medicine and biology. General subjects of interest include the design, characterization, testing, modeling and clinical validation of microfabricated systems, and their integration on-chip and in larger functional units. The specific interests of the Journal include systems for neural stimulation and recording, bioseparation technologies such as nanofilters and electrophoretic equipment, miniaturized analytic and DNA identification systems, biosensors, and micro/nanotechnologies for cell and tissue research, tissue engineering, cell transplantation, and the controlled release of drugs and biological molecules. Contributions reporting on fundamental and applied investigations of the material science, biochemistry, and physics of biomedical microdevices and nanotechnology are encouraged. A non-exhaustive list of fields of interest includes: nanoparticle synthesis, characterization, and validation of therapeutic or imaging efficacy in animal models; biocompatibility; biochemical modification of microfabricated devices, with reference to non-specific protein adsorption, and the active immobilization and patterning of proteins on micro/nanofabricated surfaces; the dynamics of fluids in micro-and-nano-fabricated channels; the electromechanical and structural response of micro/nanofabricated systems; the interactions of microdevices with cells and tissues, including biocompatibility and biodegradation studies; variations in the characteristics of the systems as a function of the micro/nanofabrication parameters.