Clinical impact of air pollution on SPECT myocardial perfusion imaging

IF 10.3 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Océane Bouchot , Stephan Gabet , Loïc Djaileb , Aurélia Robin , Nicolas De Leiris , Julie Roux , Laurent Riou , Gerald Vanzetto , Daniel Fagret , Catherine Ghezzi , Rémy Slama , Gilles Barone-Rochette
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引用次数: 0

Abstract

Background

Air pollution contributes to cardiovascular morbimortality. Air pollution effects on cardiovascular function assessed from non-invasive and invasive imaging have been reported but never on myocardial perfusion. This study aimed to characterize relations of air pollution exposure to myocardial perfusion imaging (MPI).

Methods

Patients referred to SPECT (single-photon emission computed tomography) MPI were prospectively enrolled between 2017 and 2020. Myocardial ischemia was assessed from the SPECT. Moderate-to-severe ischemia was defined as a > 10 % ischemic myocardium. Exposures to particulate matter (PM2.5 and PM10) and NO2 at the home address were characterized via a 10-meter resolution air pollutant-dispersion model and air quality monitoring system data. Associations of exposures with scintigraphy parameters were assessed through multivariable regressions, and potential modifying effects by sex and BMI were investigated.

Results

A total of 1,585 participants were prospectively included (mean age 67.7 ± 11.6 years, 63.3 % male); 148 (9.3 %) patients presented a moderate-to-severe ischemia. In multivariate analysis, the odds of moderate-to-severe ischemia was increased, with adjusted odds-ratio (ORa) of 1.39 [95 % confidence interval (95 % CI): 1.07–1.80; p = 0.013], 1.33 (95 % CI: 1.01–1.75; p = 0.042), and 1.22 (95 % CI: 0.96–1.57; p = 0.10) for each increase of one Interquartile Range (IQR) in PM2.5, PM10 and NO2 exposure, respectively (IQR equal to 3.3, 4.3 and 10.0 µg/m3, respectively). With further adjustment for cardiometabolic diseases and symptoms, only the association with PM2.5 remained statistically significant: ORa 1.34 (95 % CI: 1.03–1.75, p = 0.031) for each one-IQR increase. Associations with PM10 and PM2.5 tended to be stronger in women (interaction p-value equal to 0.11 and 0.077, respectively).

Conclusion

We provide new insights into a mechanism by which particulate air pollution may influence cardiovascular risk. Exposure to PM was associated with moderate-to-severe ischemia, particularly in women.
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来源期刊
Environment International
Environment International 环境科学-环境科学
CiteScore
21.90
自引率
3.40%
发文量
734
审稿时长
2.8 months
期刊介绍: Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.
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