Environmental Pollutants, Occupational Exposures, and Liver Disease.

IF 3.7 3区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Seminars in liver disease Pub Date : 2025-06-01 Epub Date: 2025-03-21 DOI:10.1055/a-2540-2861
Juliane I Beier, Jianzhu Luo, Charis-Marie Vanderpuye, Paxton Brizendine, Pooja Muddasani, Oluwanifemiesther Bolatimi, Shannon A Heinig, Frederick A Ekuban, Hamda Siddiqui, Abigail Ekuban, Tyler C Gripshover, Banrida Wahlang, Walter H Watson, Matthew C Cave
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引用次数: 0

Abstract

Environmental pollutants significantly impact liver disease development, progression, and outcomes. This review examines the complex relationship between environmental exposures and liver pathology, from malignant conditions like hepatocellular carcinoma to steatotic and cholestatic liver diseases. Key environmental factors include air pollutants, volatile organic compounds, persistent organic pollutants, heavy metals, and per- and polyfluoroalkyl substances. These compounds can act through multiple mechanisms, including endocrine disruption, metabolic perturbation, oxidative stress, and direct hepatotoxicity. The impact of these exposures is often modified by factors such as sex, diet, and genetic predisposition. Recent research has revealed that even low-level exposures to certain chemicals can significantly affect liver health, particularly when combined with other risk factors. The emergence of exposomics as a research tool promises to enhance our understanding of how environmental factors influence liver disease. Importantly, exposure effects can vary by demographic and socioeconomic factors, highlighting environmental justice concerns. Implementation of this knowledge in clinical practice requires new diagnostic approaches, healthcare system adaptations, and increased awareness among medical professionals. In conclusion, this review provides a comprehensive examination of current evidence linking environmental exposures to liver disease and discusses implications for clinical practice and public health policy.

环境污染物、职业暴露与肝脏疾病。
环境污染物对肝脏疾病的发生、发展和结果有着重大影响。本综述探讨了环境暴露与肝脏病理之间的复杂关系,包括肝细胞癌等恶性疾病以及脂肪肝和胆汁淤积性肝病。主要环境因素包括空气污染物、挥发性有机化合物、持久性有机污染物、重金属以及全氟和多氟烷基物质。这些化合物可通过多种机制发挥作用,包括干扰内分泌、扰乱新陈代谢、氧化应激和直接肝毒性。性别、饮食和遗传易感性等因素通常会改变这些暴露的影响。最近的研究发现,即使是低水平接触某些化学物质,也会对肝脏健康产生重大影响,尤其是在与其他风险因素相结合的情况下。作为一种研究工具,暴露组学的出现有望增进我们对环境因素如何影响肝病的了解。重要的是,暴露的影响可能因人口和社会经济因素而异,这凸显了环境正义问题。将这些知识应用于临床实践需要新的诊断方法、医疗保健系统的调整以及医疗专业人员意识的提高。总之,本综述全面考察了环境暴露与肝病相关的现有证据,并讨论了对临床实践和公共卫生政策的影响。
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来源期刊
Seminars in liver disease
Seminars in liver disease 医学-胃肠肝病学
CiteScore
8.20
自引率
2.40%
发文量
38
期刊介绍: Seminars in Liver Disease is a quarterly review journal that publishes issues related to the specialties of hepatology and gastroenterology. As the premiere review journal in the field, Seminars in Liver Disease provides in-depth coverage with articles and issues focusing on topics such as cirrhosis, transplantation, vascular and coagulation disorders, cytokines, hepatitis B & C, Nonalcoholic Steatosis Syndromes (NASH), pediatric liver diseases, hepatic stem cells, porphyrias as well as a myriad of other diseases related to the liver. Attention is also given to the latest developments in drug therapy along with treatment and current management techniques. Seminars in Liver Disease publishes commissioned reviews. Unsolicited reviews of an exceptional nature or original articles presenting remarkable results will be considered, but case reports will not be published.
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