Associations Between Metals and Nonmetals in Drinking Water, Cardiovascular Events, and Diet

JACC advances Pub Date : 2025-03-20 DOI:10.1016/j.jacadv.2025.101669

Hanxu Shi PhD , Mintao Su MPH , Peng Shen BA , Junxiong Ma PhD , Qinfeng Zhou PhD , Zongming Yang PhD , Pengfei Chai BA , Shengzhi Sun PhD , Hongbo Lin BA , Liming Shui MPH , Zhisheng Liang MPH , Shuyu Huang MPH , Na Zhang PhD , Jianbing Wang PhD , Kun Chen MD , Zhenyu Zhang PhD

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引用次数: 0

Abstract

Background

Metals and nonmetals in drinking water could potentially influence cardiovascular health. The relationship between poor-quality drinking water, major adverse cardiovascular events (MACE), and diet is not well studied.

Objectives

The aim of this study was to determine whether long-term exposure to metals (copper, manganese, aluminum, zinc, and cadmium) and nonmetals (selenium, sulfate, and nitrate-nitrogen) in drinking water was associated with MACE outcomes, and whether the dietary patterns could modify the association between long-term exposure to low-quality drinking water and MACE.

Methods

Data from a prospective population-based cohort from Yinzhou District, Ningbo (follow-up between 2016 and 2022) were linked to Yinzhou Health Information System. MACE endpoints included acute myocardial infarction (AMI), heart failure, stroke, angina, and cardiovascular death. Effect modification of the associations between exposure and MACE by dietary factors was determined.

Results

In the final cohort of 24,212 participants, 57 had an AMI; 886 developed heart failure; 733 had a stroke; 23 had angina; and 134 had a cardiovascular death. An increased risk of: 1) AMI was seen with exposure to copper, aluminum, cadmium, and selenium; 2) stroke with exposure to zinc, copper, and selenium; 3) angina with exposure to zinc and copper; and 4) cardiovascular death with exposure to zinc and aluminum in drinking water. Consuming fish, white meat, and grain products attenuated MACE outcomes induced by metals and nonmetals in drinking water.

Conclusions

In this study, long-term exposure to higher metallic and nonmetallic elements in drinking water was associated with an increased risk of MACE. Specific dietary patterns modified the associations. Further studies are needed in this area.

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饮用水中金属和非金属、心血管事件和饮食之间的关系。

背景：饮用水中的金属和非金属可能潜在地影响心血管健康。劣质饮用水、主要心血管不良事件（MACE）和饮食之间的关系尚未得到很好的研究。目的：本研究的目的是确定长期暴露于饮用水中的金属（铜、锰、铝、锌和镉）和非金属（硒、硫酸盐和硝酸盐氮）是否与MACE结果相关，以及饮食模式是否可以改变长期暴露于低质量饮用水和MACE之间的关系。方法：来自宁波市鄞州区的前瞻性人群队列数据（随访时间为2016年至2022年）与鄞州卫生信息系统相关联。MACE终点包括急性心肌梗死（AMI）、心力衰竭、中风、心绞痛和心血管死亡。确定了饮食因素对暴露与MACE之间关系的影响。结果：在24,212名参与者的最终队列中，57人患有AMI；886人出现心力衰竭；733人中风；心绞痛23例；134人死于心血管疾病。1)接触铜、铝、镉和硒会增加AMI的风险；2)接触锌、铜、硒的中风；3)锌、铜暴露引起的心绞痛；4)饮用水中锌和铝的暴露与心血管死亡有关。食用鱼类、白肉和谷物制品可减轻饮用水中金属和非金属引起的MACE结果。结论：在本研究中，长期暴露于饮用水中较高的金属和非金属元素与MACE风险增加有关。特定的饮食模式改变了这种联系。这方面还需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JACC advances Cardiology and Cardiovascular Medicine

CiteScore

1.90

自引率

0.00%

发文量