Elevated serum angiotensin ii levels in children and adolescents with anxiety disorders

IF 3.4 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology Pub Date : 2025-03-15 DOI:10.1016/j.psyneuen.2025.107430

Çiğdem Tanrıverdi , Ömer Başay , İhsan Kara , Esen Yıldırım Demirdöğen , Fatma Betül Özgeriş , Büşra Nur Akgül

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引用次数: 0

Abstract

Purpose

Angiotensin II peptide is implicated in oxidative stress, neuropathology, and the serotonergic system. We investigated the serum angiotensin II levels in non-medicated children and adolescents with anxiety disorders.

Materials and Methods

Thirty-nine children and adolescents diagnosed with anxiety disorders and thirty-five controls participated in this study to investigate the potential association between anxiety disorders and serum angiotensin II levels. Parents of the participants completed the RCADS-P parent version to assess their children’s anxiety and depression levels.

Results

Higher serum angiotensin II levels were found in individuals with anxiety disorders compared to the control group. We found that social phobia, panic disorder, low mood (major depressive disorder), and generalized anxiety disorder subscale scores on the RCADS-P were significantly correlated with angiotensin II levels.

Conclusions

We found that children and adolescents with anxiety disorders had higher serum angiotensin II levels. The current findings align with previous research on the role of angiotensin II in other mental health conditions. Further research is necessary to elucidate its role in anxiety disorders.

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来源期刊

Psychoneuroendocrinology 医学-精神病学

CiteScore

7.40

自引率

8.10%

发文量

268

审稿时长

66 days

期刊介绍： Psychoneuroendocrinology publishes papers dealing with the interrelated disciplines of psychology, neurobiology, endocrinology, immunology, neurology, and psychiatry, with an emphasis on multidisciplinary studies aiming at integrating these disciplines in terms of either basic research or clinical implications. One of the main goals is to understand how a variety of psychobiological factors interact in the expression of the stress response as it relates to the development and/or maintenance of neuropsychiatric illnesses.