Application of an AI-Based Model for Non-Invasive Sonographic Assessment for Injection Laryngoplasty.

IF 2.6 3区 医学 Q1 OTORHINOLARYNGOLOGY
Otolaryngology- Head and Neck Surgery Pub Date : 2025-07-01 Epub Date: 2025-03-21 DOI:10.1002/ohn.1215
Wen-Hsuan Tseng, Ming-Sui Lee, Shung-Cyuan Hong, Tzu-Yu Hsiao, Tsung-Lin Yang
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引用次数: 0

Abstract

Objective: Hyaluronic acid (HA) can be degraded over time. However, the persistence of the effects after injection laryngoplasty (IL) for unilateral vocal fold paralysis (UVFP) has been observed. The relation between HA residue and clinical voice outcomes is undetermined. We aimed to develop a non-invasive method with clinical applicability for objective evaluation of the temporal change in HA volume using artificial intelligence-based ultrasonographic assessment. Furthermore, the volume outcome and its relation to voice outcomes were investigated.

Study design: A prospective cohort study.

Setting: A voice clinic at a tertiary medical center.

Methods: Adult patients who underwent HA IL for UVFP were recruited. The Voice Handicap Index-10 questionnaire, the grade, roughness, breathiness, asthenia, strain scale, and the normalized glottal gap were evaluated before IL. Patients received ultrasonography for the identification of HA and estimation of volume based on Temporal Convolutional Segmentation Network, and also voice outcome assessments at 2 weeks, and 2 and 6 months after IL.

Results: Contours of HA were well-described, and volumes were estimated accordingly. Clinical voice outcomes were significantly improved postoperatively and remained stationary. Contrarily, residual HA volume decreased significantly across time points (1.21 ± 0.53 at 2 weeks, 0.63 ± 0.35 at 2 months, P < .001; 0.32 ± 0.25 at 6 months, P < .001). Simple linear regression showed no significant relationship between the remaining volume at 2 months and patient age or duration of symptoms (P = .67).

Conclusion: Volume change of injected HA over time was estimated non-invasively. The prolonged voice improvement, longer than HA longevity, was demonstrated objectively. The knowledge on HA longevity and duration of benefit provides perspectives beneficial to counseling patients and future treatment planning.

人工智能模型在喉成形术无创超声评估中的应用。
目的:透明质酸(HA)可以随着时间的推移而降解。然而,注射喉成形术(IL)治疗单侧声带麻痹(UVFP)后的效果持续存在。血凝素残留与临床语音结果之间的关系尚不确定。我们的目的是开发一种无创的、临床适用的方法,使用基于人工智能的超声评估来客观评估HA体积的时间变化。此外,研究了音量结果及其与语音结果的关系。研究设计:前瞻性队列研究。环境:三级医疗中心的语音诊所。方法:招募因UVFP接受HA IL治疗的成年患者。在IL前对患者进行嗓音障碍指数-10问卷、分级、粗糙度、呼吸、无力、应变量表和归一化声门间隙的评估。患者在IL后2周、2个月和6个月接受超声检查,以识别HA和估计体积,并评估语音结果。结果:HA的轮廓得到很好的描述,相应的体积估计。术后临床语音结果显著改善并保持平稳。相反,HA残留体积在不同时间点上明显下降(2周时为1.21±0.53,2个月时为0.63±0.35)。P结论:注射HA体积随时间变化无创。客观地证明了延长的语音改善,比HA寿命更长。关于HA寿命和受益持续时间的知识为咨询患者和未来的治疗计划提供了有益的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Otolaryngology- Head and Neck Surgery
Otolaryngology- Head and Neck Surgery 医学-耳鼻喉科学
CiteScore
6.70
自引率
2.90%
发文量
250
审稿时长
2-4 weeks
期刊介绍: Otolaryngology–Head and Neck Surgery (OTO-HNS) is the official peer-reviewed publication of the American Academy of Otolaryngology–Head and Neck Surgery Foundation. The mission of Otolaryngology–Head and Neck Surgery is to publish contemporary, ethical, clinically relevant information in otolaryngology, head and neck surgery (ear, nose, throat, head, and neck disorders) that can be used by otolaryngologists, clinicians, scientists, and specialists to improve patient care and public health.
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