Characterizing hepatic porphyria: Insights from a quaternary care hospital in Bogotá, Colombia (2013-2023).

IF 1.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Journal of International Medical Research Pub Date : 2025-03-01 Epub Date: 2025-03-21 DOI:10.1177/03000605251325183
María C Martínez-Ávila, Eugenio Matijasevic-Arcila, Stefania Pantoja-Chica, Alieth L Acosta-Cardozo
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引用次数: 0

Abstract

IntroductionAcute hepatic porphyrias are rare, life-threatening genetic disorders that impair heme biosynthesis, often presenting with nonspecific symptoms that lead to misdiagnosis. This diagnostic challenge and low clinical recognition can delay targeted treatment, increasing morbidity and mortality. Although there have been advances in understanding porphyrias' biochemical pathways, improved diagnostic approaches are still needed, especially in acute care. This study examined diagnostic and clinical patterns of acute hepatic porphyria at a quaternary care hospital in Bogotá, Colombia, to support earlier detection and management.Materials and MethodsThis descriptive, observational, retrospective study reviewed patients diagnosed with acute hepatic porphyria at the Internal Medicine service of a Bogotá hospital from 2013 to 2023. Patients with confirmed diagnoses recorded in the hospital database were included. Data collected covered demographic characteristics, clinical presentation, diagnostic markers, and treatment. Key outcome measures were time to diagnosis, recurrence frequency, and hospitalization duration.ResultsTen patients were included, 80% of whom were female, with a median age of 32 years. Diagnosis was confirmed by urine porphobilinogen tests. All patients reported abdominal pain during attacks; 90% had tachycardia and paresis/weakness of extremities. Attack durations ranged from 4 to 11 days, with 90% treated with hemin. Median hospital stay was 18 days. Drug use and infections were common precipitants, and 40% of female patients had premenstrual-associated attacks.ConclusionsThis study provides a clinical profile of acute hepatic porphyria in a Colombian hospital, highlighting neurovisceral symptoms and female predominance. Findings suggest the need for early diagnostic protocols to prevent treatment delays, although larger studies are required to confirm these findings across different settings.

肝卟啉症的特征:来自哥伦比亚波哥大一家四级护理医院的见解(2013-2023 年)。
急性肝性卟啉症是一种罕见的、危及生命的遗传性疾病,它损害血红素的生物合成,通常表现为导致误诊的非特异性症状。这种诊断挑战和低临床认知度会延迟靶向治疗,增加发病率和死亡率。虽然在了解卟啉症的生化途径方面已经取得了进展,但改进的诊断方法仍然需要,特别是在急性护理中。本研究在哥伦比亚波哥大的一家第四保健医院检查了急性肝性卟啉症的诊断和临床模式,以支持早期发现和管理。材料和方法本描述性、观察性、回顾性研究回顾了2013年至2023年波哥大医院内科诊断为急性肝性卟啉症的患者。纳入医院数据库中记录的确诊患者。收集的数据包括人口统计学特征、临床表现、诊断标记和治疗。主要观察指标为诊断时间、复发频率和住院时间。结果纳入患者10例,女性占80%,中位年龄32岁。尿卟啉胆色素原试验证实诊断。所有患者均报告发作时腹痛;90%有心动过速和四肢麻痹/无力。发作时间从4天到11天不等,90%的患者用血红蛋白治疗。平均住院时间为18天。药物使用和感染是常见的诱发因素,40%的女性患者有经前相关发作。结论:本研究提供了哥伦比亚一家医院急性肝性卟啉症的临床概况,突出了神经内脏症状和女性优势。研究结果表明,需要早期诊断方案以防止治疗延误,尽管需要更大规模的研究来证实不同环境下的这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.20
自引率
0.00%
发文量
555
审稿时长
1 months
期刊介绍: _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605
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