The effect of fish oil versus krill oil intervention on clinical symptoms and cardiometabolic risk factors in patients with major depressive disorder: A randomized placebo-controlled double-blind trial

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-03-19 DOI:10.1016/j.jad.2025.03.097

Murat Açik , Funda Pınar Çakiroğlu , Atilla Tekin , Aslı Egeli

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引用次数: 0

Abstract

Background

This study aimed to compare the effects of krill- and fish-oil interventions on clinical symptoms and metabolic risk factors in individuals with MDD.

Methods

In this randomized study, 57 adults diagnosed with MDD were allocated to receive krill-oil (520 mg EPA + DHA), fish-oil (600 mg EPA + DHA), or a placebo (soybean-oil) daily for 8 weeks. Anthropometric measurements, depression anxiety stress-21 (DASS-21) scale, and Hamilton depression rating scale (HDRS) were performed at baseline and 4 and 8 weeks. In addition, venous blood samples were collected at baseline and post-intervention to evaluate lipid and glycemic profiles, including fasting glucose, HbA1c, cholesterol, triglycerides, LDL-c, and HDL-c levels.SPSS and R Studio software programs were used for statistical analysis.

Results

A total of 50 participants completed the study, with 17 in each intervention group and 16 in the placebo. The mean HDRS scores decreased significantly in both the krill-oil (8.5 ± 1.2) and fish-oil groups (10.0 ± 1.2) compared to the placebo (p < 0.001), indicating clinical symptom improvement. Furthermore, the interaction effect of group-by-time was found to be statistically significant (η2p = 0.273;p_time×group < 0.001). Anxiety and distress scores decreased to similar levels after the post-intervention compared to baseline in krill- and fish-oil groups. Krill- and fish-oil supplementation increased plasma HDL-c and uric acid levels, but the group-by-time interaction effect was only observed at the HDL-c level (η2p = 0.238;p_time×group = 0.002). The mean HbA1c rates and plasma triglyceride levels of krill-oil recipients were lower after the post-intervention.

Conclusion

Krill- and fish-oil could be considered as a safe and effective adjuvant treatments for depression. However, there was no evidence of apparent superiority over each other.

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.